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Thiol/Disulphide Homeostasis and Albumin in Vertigo

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
Kiungo kimehifadhiwa kwenye clipboard
HaliImekamilika
Wadhamini
Ankara City Hospital Bilkent
Washirika
Ankara Training and Research Hospital

Maneno muhimu

Kikemikali

Vertigo is a common complaint in the Emergency Department (ED). The differential diagnosis of central and peripheral vertigo is a difficult issue that directly affects mortality. Magnetic resonance imaging (MRI) is the preferred diagnostic tool, but may not be suitable in all patients due to logistic and economic conditions. In this study, the investigators evaluated the role of thiol/disulfide homeostasis (TDH) parameters and ischemia modified albumin (IMA) levels to assist in the value of being used instead of MRI.

Maelezo

The study was conducted in the ED using a prospective, non-randomized method, and included patients with complaints of acute onset vertigo over 18 years of age and who underwent brain MRI. Pregnant women, smokers, and those with significant neurological signs were excluded. Patients with acute ischemia with MRI were included in the central vertigo group, and patients with normal MRI were included in the peripheral vertigo group. Blood samples for native thiol (NT), total thiol (TT), disulfide, and IMA were collected from all patients at admission. Statistical analyzes were performed with IBM SPSS Statistics for Windows 16.0 Package Program.

Tarehe

Imethibitishwa Mwisho: 07/31/2019
Iliyowasilishwa Kwanza: 08/21/2019
Uandikishaji uliokadiriwa Uliwasilishwa: 08/23/2019
Iliyotumwa Kwanza: 08/27/2019
Sasisho la Mwisho Liliwasilishwa: 08/23/2019
Sasisho la Mwisho Lilichapishwa: 08/27/2019
Tarehe halisi ya kuanza kwa masomo: 06/30/2018
Tarehe ya Kukamilisha Msingi iliyokadiriwa: 12/30/2018
Tarehe ya Kukamilisha Utafiti: 12/30/2018

Hali au ugonjwa

Vertigo, Peripheral
Vertigo, Central Origin
Oxidative Stress
Diagnosis

Awamu

-

Vikundi vya Arm

MkonoUingiliaji / matibabu
Central vertigo
Patients without any pathology on MRI were included in the peripheral vertigo group, and patients whose scans demonstrated acute ischemic infarct in the posterior fossa were included in the central vertigo group.
Peripheral vertigo
Patients without any pathology on MRI were included in the peripheral vertigo group, and patients whose scans demonstrated acute ischemic infarct in the posterior fossa were included in the central vertigo group.

Vigezo vya Kustahiki

Zama zinazostahiki Kujifunza 51 Years Kwa 51 Years
Jinsia Inastahiki KujifunzaAll
Njia ya sampuliNon-Probability Sample
Hupokea Wajitolea wa AfyaNdio
Vigezo

Inclusion Criteria:

- Patients with complaint of vertigo

- Patients over18 years of age

Exclusion Criteria:

- Patients contraindicated for MRI due to metal prosthesis or claustrophobia

- Patients under 18 years of age

- Pregnant patients

- Tobacco users

- Patients exhibiting significant neurological signs or symptoms such as motor or sensory neurologic deficit, speech disorders, unconsciousness, or seizure

- Patients found to have any type of lesion such as a hematoma, mass, cyst, aneurysm, arteriovenous malformation, etc. other than ischemic infarcts on MRI

- Patients with an ischemic lesion other than posterior fossa lesions

- Patients with any type of infection, including upper respiratory tract and ear infections

- Patients previously diagnosed with peripheral vertigo

- Patients where the cause of lightheadedness was blood pressure disorders, cardiac ischemic and arrhythmic disorders, thromboembolic diseases, metabolic disorders, trauma, etc. rather than central and peripheral vertigo.

Matokeo

Hatua za Matokeo ya Msingi

1. Oxidative stress [6 months]

Thiol/disulphide homeostasis

2. Ischemic status [6 months]

Ischemia modified albumin

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