Uncomplicated Nausea and Vomiting in the Emergency Department

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Kiungo kimehifadhiwa kwenye clipboard

HaliImekamilika

Wadhamini

WellSpan Health

JARIBIO LA KLINIKI: NCT00778011

BioSeek: nct00778011

Maneno muhimu

Kikemikali

Nausea and vomiting is a common complaint in the emergency department. Treatment is important for many reasons. In addition to patient comfort, there are adverse effects secondary to vomiting such as dehydration, metabolic alkalosis, Mallory-Weiss tears, and aspiration. Two mediations common used for nausea in ED patients include Ondanesetron and Metoclopramide.

Maelezo

This study will compare Ondansetron 4 mg vs 2 mg vs Metoclopramide 10 mg to look for efficacy in nausea and vomiting treatment for patients in the ED with many different causes. We will also look for cost effectiveness as well, since Metoclopramide is much less expensive than Ondansetron, which is less expensive at lower doses. There is little research about nausea medication in the ED literature even though these medications are used frequently in the ED for many causes of nausea.

Tarehe

Imethibitishwa Mwisho:	05/31/2012
Iliyowasilishwa Kwanza:	10/21/2008
Uandikishaji uliokadiriwa Uliwasilishwa:	10/21/2008
Iliyotumwa Kwanza:	10/22/2008
Sasisho la Mwisho Liliwasilishwa:	06/26/2012
Sasisho la Mwisho Lilichapishwa:	06/27/2012
Tarehe halisi ya kuanza kwa masomo:	10/31/2005
Tarehe ya Kukamilisha Msingi iliyokadiriwa:	11/30/2006
Tarehe ya Kukamilisha Utafiti:	11/30/2006

Hali au ugonjwa

Nausea

Vomiting

Uingiliaji / matibabu

Drug: 1

Drug: 2

Drug: 3

Awamu

Awamu 4

Vikundi vya Arm

Mkono	Uingiliaji / matibabu
Active Comparator: 1	Drug: 1 dosage
Active Comparator: 2	Drug: 2 4 mg
Active Comparator: 3	Drug: 3 10 mg IV

Vigezo vya Kustahiki

Zama zinazostahiki Kujifunza	18 Years Kwa 18 Years
Jinsia Inastahiki Kujifunza	All
Hupokea Wajitolea wa Afya	Ndio
Vigezo	Inclusion Criteria: - 18 years or older with nausea and at least 1 episode vomiting in the last 12 hours presenting to the York Hospital Emergency Department Exclusion Criteria: - Patients known to have hypersensitivity to the drugs ondansetron or metoclopramide - gastrointestinal hemorrhage, mechanical obstruction or perforation - patients with pheochromocytoma - seizure disorder - patients receiving other drugs which are likely to cause extrapyramidal reactions such as butapherones and phenothiazines - patients experiencing hyperemesis gravidum - patients unable to understand the informed consent (intoxicated, Spanish speaking) - prior antiemetics within 12 hours - inability to perform visual analog scale - renal dialysis

Matokeo

Hatua za Matokeo ya Msingi

1. To delineate whether a high vs low dose of Ondansetron in better as opposed to an alternate medication -- Metoclopramide in the ED setting for uncomplicated nausea and vomiting. [30 minutes]