Zinc Bioavailability From Amaranth-enriched Maize Tortillas

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Kiungo kimehifadhiwa kwenye clipboard

HaliImekamilika

Wadhamini

University of Colorado, Denver

Washirika

International Atomic Energy Agency

Universidad Francisco Marroquín

JARIBIO LA KLINIKI: NCT02208609

BioSeek: nct02208609

Maneno muhimu

Kikemikali

Young children in Guatemala are at risk for nutrient deficiencies due to plant-based diets and poor sanitation. Stunting, frequent diarrhea, and respiratory infections are common. Supplementation of Zn to children during diarrhea episodes has been shown to diminish duration and severity of illness. Poor Zn absorption due to high fiber and phytate in this diet might play a role in these processes. Supplementation of this micronutrient in the diet might be beneficial. The investigators will compare absorption of Zn from white maize tortillas enriched with 20% amaranth to traditional white corn tortillas in preschool children in Guatemala.

Maelezo

This is a randomized cross-over study of zinc absorption in young children living in the Western Highlands of Guatemala. Absorption of zinc will be measured from maize tortillas and maize tortillas fortified with 20% amaranth as the major food staple which provides at least 70% energy and at least 90% zinc and phytate of the diet. Participants will be randomized as to which type of tortilla they receive on the first and second day. Fractional absorption of zinc (FAZ) from all meals in one day for one type of tortilla and one day for the other will be measured by extrinsic labeling with stable isotopes of zinc. FAZ will be measured by a dual isotope tracer ratio (DITR) technique based on ratio of urine enrichment of orally versus intravenously administered zinc stable isotopes. Measurement of total zinc in duplicate diets on test days allow for determination of quantities of this micronutrient absorbed.

Tarehe

Imethibitishwa Mwisho:	03/31/2016
Iliyowasilishwa Kwanza:	07/31/2014
Uandikishaji uliokadiriwa Uliwasilishwa:	08/03/2014
Iliyotumwa Kwanza:	08/04/2014
Sasisho la Mwisho Liliwasilishwa:	04/26/2016
Sasisho la Mwisho Lilichapishwa:	04/28/2016
Tarehe halisi ya kuanza kwa masomo:	12/31/2011
Tarehe ya Kukamilisha Msingi iliyokadiriwa:	11/30/2015
Tarehe ya Kukamilisha Utafiti:	11/30/2015

Hali au ugonjwa

Nutritional Deficiency

Uingiliaji / matibabu

Other: Maize Tortillas with 20% Amaranth

Other: Maize Tortillas without 20% Amaranth

Awamu

Vikundi vya Arm

Mkono	Uingiliaji / matibabu
Experimental: Maize Tortillas with 20% Amaranth Children in this arm were fed maize tortillas fortified with 20% amaranth	Other: Maize Tortillas with 20% Amaranth Subjects received Maize tortillas with 20% Amaranth added.
Experimental: Maize Tortillas without 20% Amaranth Children in this arm were fed maize tortillas without amaranth	Other: Maize Tortillas without 20% Amaranth Maize tortillas without Amaranth.

Vigezo vya Kustahiki

Zama zinazostahiki Kujifunza	18 Months Kwa 18 Months
Jinsia Inastahiki Kujifunza	All
Hupokea Wajitolea wa Afya	Ndio
Vigezo	Inclusion Criteria: - 2-3 years of age - apparently healthy - eats >2-3 tortillas at each meal of the day. Exclusion Criteria: - Chispitas or macrovital supplementation - breastfeeding - birth weight < 2,500 g - birth defect affecting growth and development - chronic infection - twin or triplet - sibling enrolled in study

Matokeo

Hatua za Matokeo ya Msingi

1. Zinc Absorption [2 days]

Absorption of zinc will be compared in young children when fed the common maize tortilla and a tortilla fortified with 20 % amaranth.. Fractional absorption of zinc for a day will be measured by extrinsic labeling with stable isotopes of zinc. Fractional absorption of zinc will be measured by a dual isotope tracer ratio technique. Measurement of total zinc in duplicate diets on test day will allow determination of quantity of this micronutrient absorbed (mg/d).