[Antiallergic effect of D-glucuronic acid].

The influence of D-glucuronic acid (course administration) on a Thl and Th2 immune response was studied. It is established that D-glucuronic acid suppressed Th2-dependent immune response as it decreased the lethality from the anaphylactic shock, abolished the local anaphylactic reaction and strongly inhibited allergen-specific IgE and IgG1 production. In addition, D-glucuronic acid stimulated Thl-dependent immune response since it enhanced the delay-type hypersensitivity reaction, increased amount of antibody-forming cells and the number of antibodies in blood. It is concluded that the mechanism of the antiallergic effect of D-glucuronic acid is related to a change in the Th1/Th2 balance in favor of Th1.