Antiplasmodial activity of ineupatorolides A from Carpesium rosulatum.
Maneno muhimu
Kikemikali
Samples of Carpesium genus used as traditional remedies for the treatment of parasite infections were collected, and methanol extracts were obtained by sonication. The ethylacetate-, n-butanol- and H(2)O-soluble fractions exhibited weak antiplasmodial activity (IC(50) > 100 microg/ml; IC(50), 50% inhibitory concentration). However, the chloroform fraction exhibited more impressive antiplasmodial activity (IC(50) = 8.2 microg/ml). The antiplasmodial activity of the chloroform fractions was evaluated in vitro against the chloroquine-resistant D10 strain of Plasmodium falciparum. Bioactivity-guided isolation of the chloroform fractions of the whole plants of Carpesium rosulatum has led to the isolation of a sesquiterpene lactone, ineupatorolides A, displaying high antiplasmodial activity (IC(50) = 0.007 microg/ml). This is the first report of the isolation of ineupatorolides A from this species and of its remarkable antiplasmodial activity.