Fitoterapia 2017-Sep

Cytotoxic aspidofractinine alkaloids from Kopsia hainanensis.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

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Ying Wang

Lei Hang

Li Jiao

Hui Liu

Fei Li

KIFUNGU: 28663081

DOI: 10.1016/j.fitote.2017.06.023

BioSeek: 28663081

Maneno muhimu

Kikemikali

Five new aspidofractinine-type alkaloids, kopsiahainins A-E (1-5), were isolated from a 80% EtOH extract of the leaves and stems of Kopsia hainanensis. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D-NMR, IR, UV, and HR-ESI-MS. Alkaloids 3 and 4 exhibited some cytotoxic activity against all of six tested tumor cell lines (BGC-823, HepG2, MCF-7, SGC-7901, SK-MEL-2, and SK-OV-3) with IC50 values of 7.3-9.5μM and 9.2-10.6μM, respectively.

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Cytotoxic aspidofractinine alkaloids from Kopsia hainanensis.

Maneno muhimu

saratani

alkaloid

kopsia

kopsia hainanensis

Kikemikali

Hifadhidata kamili ya mimea ya dawa inayoungwa mkono na sayansi