Journal of Natural Products 2011-May

Grandilodines A-C, biologically active indole alkaloids from Kopsia grandifolia.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Kiungo kimehifadhiwa kwenye clipboard

Wai-Sum Yap

Chew-Yan Gan

Yun-Yee Low

Yeun-Mun Choo

Tadahiro Etoh

Masahiko Hayashi

Kanki Komiyama

Toh-Seok Kam

KIFUNGU: 21428274

DOI: 10.1021/np200008g

BioSeek: 21428274

Maneno muhimu

Kikemikali

Three new indole alkaloids (1-3), named grandilodines A-C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established using NMR and MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells.

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Herbal & Natural Medicine

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Grandilodines A-C, biologically active indole alkaloids from Kopsia grandifolia.

Maneno muhimu

vincristine

alkaloid

indole

kopsia

kopsia grandifolia

Kikemikali

Hifadhidata kamili ya mimea ya dawa inayoungwa mkono na sayansi