Bioorganic and Medicinal Chemistry 2004-Aug

Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco.

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Ingia / Ingia

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Juan C Hernández

Francisco León

José Quintana

Francisco Estévez

Jaime Bermejo

KIFUNGU: 15265493

DOI: 10.1016/j.bmc.2004.06.009

BioSeek: 15265493

Maneno muhimu

Kikemikali

This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC(50) 2.6+/-0.9microM at 72h, with growth inhibition caused by the induction of apoptosis, as determined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1.

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Herbal & Natural Medicine

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Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco.

Maneno muhimu

ribose

saponin

lukemia

dracaena

dracaena draco

Kikemikali

Hifadhidata kamili ya mimea ya dawa inayoungwa mkono na sayansi