Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor.
Maneno muhimu
Kikemikali
BACKGROUND
The insulinoma syndrome is marked by fasting hypoglycemia and inappropriate elevations of insulin. The gastrinoma syndrome is characterized by hypergastrinemia, ulcer disease, and/or diarrhea. Rarely, insulinoma and gastrinoma coexist in the same patient simultaneously.
OBJECTIVE
Our objective was to determine the cause of a patient's hypoglycemic episodes and peptic ulcer disease.
METHODS
This is a clinical case report from the Clinical Research Center of the National Institutes of Health.
METHODS
One patient with hypoglycemic episodes and peptic ulcer disease had a surgical resection of neuroendocrine tumor.
RESULTS
The patient was found to have a single tumor cosecreting both insulin and gastrin. Resection of this single tumor was curative.
CONCLUSIONS
A single pancreatic neuroendocrine tumor may lead to the expression of both the hyperinsulinemic and hypergastrinemic syndromes.
