Methods in molecular medicine 1999

Molecular Analysis in Factor XI Deficiency.

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Ingia / Ingia

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K M Johnson

J H McVey

KIFUNGU: 21340997

DOI: 10.1385/1-59259-248-1:211

BioSeek: 21340997

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Factor XI (FXI) is the zymogen precursor of an active serine protease that participates in the contact phase of coagulation. Synthesized in the liver, it circulates in the plasma in a noncovalent complex with high molecular weight kininogen (1) at a normal concentration of 5 μg/mL. (For clinical purposes, the normal range is defined as 50-150 U/dL) (2). FXI circulates as a homodimeric glycoprotein with a mass of 160 kDa.

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Herbal & Natural Medicine

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Molecular Analysis in Factor XI Deficiency.

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protease

zymogen

factor xi deficiency

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