European Journal of Pharmacology 1993-Dec

Riluzole prevents anoxic injury in cultured cerebellar granule neurons.

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Ingia / Ingia

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F Dessi

Y Ben-Ari

C Charriaut-Marlangue

KIFUNGU: 8112389

BioSeek: 8112389

Maneno muhimu

Kikemikali

Glutamate release has been reported to be involved in the neuronal death following ischemic or anoxic injury. Riluzole (2-amino-6-trifluoromethoxy-benzothiazole) is a putative inhibitor of glutamate release. We investigated the effect of this drug on anoxic injury in vitro. Cerebellar granule cells grown in culture were exposed to an anoxic atmosphere for 16-20 h, Riluzole (100 microM) was found to prevent the degeneration of these neurons induced by anoxia.

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Herbal & Natural Medicine

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Riluzole prevents anoxic injury in cultured cerebellar granule neurons.

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hypoxia

atrophy

benzothiazole

Kikemikali

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