[Study on chemical constituents of Lycopodium alkaloids].
Maneno muhimu
Kikemikali
OBJECTIVE
To study the alkaloid chemical constituents of Lycopodium japonicum.
METHODS
Compounds were isolated and purified by such methods as silica gel column chromatography, RP-C18 reversed phase column chromatography, Sephadex LH-20 column chromatography and Waters semi-preparative liquid chromatogram, and their structures were identified based on physicochemical property and spectrum data.
RESULTS
Nine known alkaloid chemical constituents were isolated and identified, they were lycodoline (1), lucidioline (2), alpha-obscurine (3), lycopodine (4), lycoposerramine-L (5), lycoposerramine-M (6), 11alpha-O-acetyl-lycopodine (7), des-N-methyl-a-obscurine (8), clavolonine (9).
CONCLUSIONS
Compounds 4-9 were obtained from L. japonicum for the first time.
