african/proline

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Proline powers pre-flight warm-up in the african fruit beetle pachnoda sinuata

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

We investigated thoracic temperatures (Tth) during different activities of the endothermic fruit beetle Pachnoda sinuata and analysed which energy substrates are used for the pre-flight warm-up of its flight muscles. Pachnoda sinuata elevates its Tth prior to take-off either by basking in the sun or

Tailoring Chemotherapy for the African-Centric S47 Variant of TP53.

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Ingia / Ingia

The tumor suppressor TP53 is the most frequently mutated gene in human cancer and serves to restrict tumor initiation and progression. Single-nucleotide polymorphisms (SNP) in TP53 and p53 pathway genes can have a marked impact on p53 tumor suppressor function, and some have been associated with

Outbreak of penicillinase-producing Neisseria gonorrhoeae with an African connection.

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Ingia / Ingia

Previous outbreaks of penicillinase-producing gonococcal infection in the United States have generally been attributed to importation of Southeast Asian strains. During July 1982 through July 1983, 110 cases of gonorrhea caused by penicillinase-producing strains were reported in metropolitan

Oculoleptomeningeal Amyloidosis associated with transthyretin Leu12Pro in an African patient.

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Ingia / Ingia

Oculoleptomeningeal amyloidosis is a rare manifestation of hereditary transthyretin (TTR) amyloidosis. Here, we present the first case of leptomeningeal amyloidosis associated with the TTR variant Leu12Pro mutation in an African patient. A 43-year-old right-handed Nigerian man was referred to our

Metabolic changes in the African fruit beetle, Pachnoda sinuata, during starvation.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Specimens of the fruit beetle Pachnoda sinuata were starved for up to 30 days. The weight of the beetles declined consistently throughout the starvation period. Concentrations of carbohydrates and alanine in flight muscles, fat body and haemolymph decreased rapidly after onset of starvation, while

Membrane association of African horsesickness virus nonstructural protein NS3 determines its cytotoxicity.

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Ingia / Ingia

The smallest RNA genome segment of African horsesickness virus (AHSV) encodes the nonstructural protein NS3 (24K). NS3 localizes in areas of plasma membrane disruption and is associated with events of viral release. Conserved features in all AHSV NS3 proteins include the synthesis of a truncated

Effects of metabolic neuropeptides from insect corpora cardiaca on proline metabolism of the African fruit beetle, Pachnoda sinuata.

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Ingia / Ingia

The effect of neuropeptides from the corpora cardiaca of the fruit beetle Pachnoda sinuata on proline metabolism has been investigated in vivo. Conspecific injections of a crude extract from corpora cardiaca cause an increase of the concentration of proline in the haemolymph by nearly 20% and a

New proline-rich oligopeptides from the venom of African adders: Insights into the hypotensive effect of the venoms.

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Ingia / Ingia

BACKGROUND The snakes from the Bitis genus are some of the most medically important venomous snakes in sub Saharan Africa, however little is known about the composition and effects of these snake venom peptides. Considering that the victims with Bitis genus snakes have exacerbate hypotension and

Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetes.

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Ingia / Ingia

African Americans have twice the prevalence of type 2 diabetes as Caucasians and much greater genetic diversity. We identified an inframe insertion of a proline in the insulin promoter factor 1 (IPF1) gene (InsCCG243), which was relatively common (minor allele frequency approximately 0.08) in

cDNA sequence and protein bioinformatics analyses of MSTN in African catfish (Clarias gariepinus).

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Ingia / Ingia

Myostatin, also known as growth differentiation factor 8, has been identified as a potent negative regulator of skeletal muscle growth. The purpose of this study was to characterize and predict function of the myostatin gene of the African catfish (Cg-MSTN). Expression of Cg-MSTN was determined at

Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans.

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Ingia / Ingia

BACKGROUND Defective insulin secretion is a key defect in the pathogenesis of type 2 diabetes (T2DM). The beta-cell specific transcription factor, insulin promoter factor 1 gene (IPF1), is essential to pancreatic development and the maintenance of beta-cell mass. We hypothesized that regulatory or

CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians.

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Ingia / Ingia

The human cytochrome P450 3A subfamily of enzymes is involved in the metabolism of steroid hormones, carcinogens, and many drugs. A cytosine-to-guanine polymorphism in CYP3A43 results in a proline-to-alanine substitution at codon 340. Although the functional significance of this polymorphism is

African trypanosomes have differentially expressed genes encoding homologues of the Leishmania GP63 surface protease.

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Ingia / Ingia

The genomes of various Leishmania parasites contain tandemly arrayed genes encoding an abundant 63-kDa surface glycoprotein called GP63. Leishmania GP63s are metalloproteases that play an important role in the invasion and survival of the parasites within the macrophage, and their presence on the

Tumor cells containing the African-Centric S47 variant of TP53 show increased Warburg metabolism.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Mutations in the TP53 tumor suppressor gene remain a hallmark of human cancer. In addition to mutation of TP53, single nucleotide polymorphisms (SNPs) in this gene can have a profound impact on p53 function, and can affect cancer risk as well as other p53 functions. Wild type (WT) p53

Breast cancer risk in relation to plasma metabolites among Hispanic and African American women.

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Ingia / Ingia

The metabolic etiology of breast cancer has been explored in the past several years using metabolomics. However, most of these studies only included non-Hispanic White individuals.To fill this gap, we performed a two-step (discovery and validation)

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Herbal & Natural Medicine

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