The present invention relates to a composition comprising a catechin compound, ascorbic acid, proline and lysine. The present invention also relates to a method for treating neoplastic disease using a composition comprising a catechin compound, ascorbic acid, proline and lysine.

Rath; Matthias

Composition and method for treatment of neoplastic diseases associated with elevated matrix metalloproteinase activities using catechin compounds

There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent, for example an anti-cancer agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid, for example a catechin-based flavonoid, wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. The suspension is useful for the delivery of the bioactive agent to cells, including cancer cells. There are also provided a therapeutic formulation comprising the suspension, as well as methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.

Kurisawa; Motoichi

Ng; Shengyong

Chung; Joo Eun

Agency for Science, Technology and Research

Particulate hyaluronic acid/flavonoid suspensions for cellular delivery of bioactive agents

There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent, for example an anti-cancer agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid, for example a catechin-based flavonoid, wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. The suspension is useful for delivery of the bioactive agent to cells, including cancer cells. There are also provided a therapeutic formulation comprising the suspension, as well as methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.

AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Particulate hyaluronic acid and flavonoid formulations for cellular delivery of bioactive agents

alpha catechin

saratani

neoplasms

alpha catechin/saratani

Composition and method for treatment of neoplastic diseases associated with elevated matrix metalloproteinase activities using catechin compounds

Particulate hyaluronic acid/flavonoid suspensions for cellular delivery of bioactive agents

Particulate hyaluronic acid and flavonoid formulations for cellular delivery of bioactive agents

Hifadhidata kamili ya mimea ya dawa inayoungwa mkono na sayansi