alpha onocerin/lycopodium clavatum

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Alpha-onocerin: an acetylcholinesterase inhibitor from Lycopodium clavatum.

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Ingia / Ingia

In order to find new acetylcholinesterase inhibitors from natural sources which have therapeutic potential in the treatment of Alzheimer's disease, the chloroform : methanol (1 : 1) extracts of five Lycopodium species ( L. clavatum L., L. selago L., L. annotinum L., L. alpinum L., and L. complanatum

Isolation of alpha-onocerin from Lycopodium clavatum Linn.

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Ingia / Ingia

Identification of Serratane Synthase Gene from the Fern Lycopodium clavatum.

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Ingia / Ingia

Ferns are known to produce onoceroids including onoceranes and serratanes having unusual structures among triterpenes. From the fern Lycopodium clavatum, a novel onoceroid synthase gene was cloned that showed high sequence identity with a previously identified α-onocerin synthase. Functional

Onocerin Biosynthesis Requires Two Highly Dedicated Triterpene Cyclases in a Fern Lycopodium clavatum.

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Ingia / Ingia

Onocerin is known for its unusual structure among triterpenoids, with a symmetrical structure that is formed by cyclizations at the both termini of dioxidosqualene. The nature of the enzyme catalyzing these unusual cyclizations has remained elusive for decades. Here, we report the cloning of genes

New insights into the acetylcholinesterase inhibitory activity of Lycopodium clavatum.

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Ingia / Ingia

Looking for acetylcholinesterase (AChE) inhibiting compounds within the plant kingdom, we came across the triterpene alpha-onocerin, which has recently been described as the active principle (IC(50) of 5.2 microM) of Lycopodium clavatum L. In order to discover related terpenoid structures with

A Single Oxidosqualene Cyclase Produces the Seco-Triterpenoid α-Onocerin.

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Ingia / Ingia

8,14-seco-Triterpenoids are characterized by their unusual open C-ring. Their distribution in nature is rare and scattered in taxonomically unrelated plants. The 8,14-seco-triterpenoid α-onocerin is only known from the evolutionarily distant clubmoss genus Lycopodium and the leguminous genus Ononis,

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Herbal & Natural Medicine

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