benzothiazol/saratani

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2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides as kinase inhibitors

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Ingia / Ingia

BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates to 2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides, their salts, pharmaceutical compositions containing them, and their use as kinase inhibitors

Method for treating cancer by combined use

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Ingia / Ingia

TECHNICAL FIELD The present invention relates to a medicament and a method for treating cancer comprising a compound having murine double minute 2 (MDM2) inhibiting activity and a compound having Fms-like tyrosine kinase 3 (FLT3) inhibiting activity in combination. BACKGROUND ART p53 is known as an

Materials and methods for sensitizing multidrug resistant cells

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Ingia / Ingia

FIELD OF INVENTION This disclosure is related to materials and methods for sensitizing multidrug resistant cancer cells to various chemotherapeutic reagents by supply compounds that reduce the activity of various ATP binding cassette (ABC) transporters. BACKGROUND Multidrug resistance (MDR) is a

Process for the preparation of imidazo[2,1-B][1,3]benzothiazole derivatives

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Ingia / Ingia

II. FIELD Provided herein are processes for the preparation of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[- 2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, or a pharmaceutically acceptable salt, solvate, hydrate, or polymorph thereof.

Carbamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors

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Ingia / Ingia

TECHNICAL FIELD This invention pertains generally to the field of biologically active compounds, and more specifically to certain carbamic acid compounds which inhibit HDAC (histone deacetylase) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds,

Carbamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors

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Ingia / Ingia

Benzoheterocyclic compounds and use thereof

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Ingia / Ingia

FIELD OF THE INVENTION The present invention relates to benzoheterocyclic compounds such as benzothiadiazole, benzoxazole and benzothiazole derivatives, which are inhibitors of protein kinases such as MEK. The compounds may be useful in the treatment of conditions or disorders where the MEK cascade

Benzoheterocyclic compounds and use thereof

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Ingia / Ingia

CROSS-REFERENCE TO RELATED APPLICATIONS This application is a National Phase application under 35 U.S.C. .sctn.371 of International Application No. PCT/CN2013/000037, filed Jan. 16, 2013, and claims the benefit of priority to People's Republic of China Patent Application No. 201210014021.X filed

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Herbal & Natural Medicine

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