benzoxazole/hepatitis

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5 matokeo

Molecular design, synthesis and cell based HCV replicon assay of novel benzoxazole derivatives.

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Ingia / Ingia

Hepatitis C virus inhibitors based on benzoxazole scaﬀold were designed based on molecular modeling simulation study including docking into the NS5B polymerase active site. Several compounds showed significant high simulation docking scores relative to the assigned benzimidazole lead compound. The

2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site.

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Ingia / Ingia

2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation

Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA.

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Ingia / Ingia

The highly conserved internal ribosome entry site (IRES) of hepatitis C virus (HCV) regulates translation of the viral RNA genome and is essential for the expression of HCV proteins in infected host cells. The structured subdomain IIa of the IRES element is the target site of recently discovered

Structure-activity relationship of new anti-hepatitis C virus agents: heterobicycle-coumarin conjugates.

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Ingia / Ingia

For establishment of the structure-activity relationship, 19 heterobicycle-coumarin conjugated compounds with the -SCH(2)- linker were synthesized and found to possess significant antiviral activities. Prominent examples included imidazopyridine-coumarin 12c, purine-coumarin 12d, and

Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores.

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Ingia / Ingia

Inhibitors of the HCV NS5A nonstructural protein are showing promising clinical potential in the treatment of hepatitis C when used in combination with other direct-acting antiviral agents. Current NS5A clinical candidates such as daclatasvir, ledipasvir, and ombitasvir share a common pharmacophore

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