benzoxazole/hypersensitivity

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NakalaMajaribio ya klinikiHati miliki

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4 matokeo

The anti-allergic activity of Benoxaprofen [2-(4-chlorophenyl)-alpha-methyl-5-benzoxazole acetic acid]--a lipoxygenase inhibitor.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Benoxaprofen [2-(4-chlorophenyl)-alpha-methyl-5-benzoxazole acetic acid], a novel anti-inflammatory compound, is also an orally-active anti-allergic compound in animals. It reduced the anaphylactic release of mediators, particularly slow-reacting substance of anaphylaxis (SRS-A), from both in vitro

Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors.

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Ingia / Ingia

5-Lipoxygenase (5-LOX) is important enzyme in the biosynthesis of leukotrienes, and is a potential target in the treatment of asthma and allergy. We designed and synthesized a series of benzoxazoles and benzothiazoles as 5-LOX inhibitors. Fourteen compounds prepared showed the inhibition of LTC4

Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation.

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Ingia / Ingia

Mast cells are central regulators of allergic inflammation that function by releasing various proallergic inflammatory mediators, including histamine, eicosanoids and proinflammatory cytokines. Occasionally, bacterial infections may initiate or worsen allergic inflammation. A number of studies have

Synthesis of benzoxazole derivatives as interleukin-6 antagonists.

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Ingia / Ingia

A growing number of studies have demonstrated that interleukin (IL)-6 plays pathological roles in the development of chronic inflammatory disease and autoimmune disease by activating innate immune cells and by stimulating adaptive inflammatory T cells. So, suppression of IL-6 function may be

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Herbal & Natural Medicine

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