benzyl amine/saratani

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New pyridone, thioxopyridine, pyrazolopyridine and pyridine derivatives that modulate inflammatory mediators in stimulated RAW 264.7 murine macrophage.

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Ingia / Ingia

The reaction of 2-acetyl-5,6,7,8-tetrahydronaphthalene 1 with some aldehydes was conducted in the presence of ethyl cyanoacetate and ammonium acetate, yielded the cyanopyridones 2a-c, which react with phosphorous pentasulphide to afford the corresponding thioxopyridine derivatives 3a-c,

Synthesis and biological evaluation of glaucocalyxin A derivatives as potential anticancer agents.

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Ingia / Ingia

A series of Mannich base type derivatives of Glaucocalyxin A (GLA) were designed and prepared. The cytotoxicity of these compounds was evaluated against six tumor cell lines (SMMC-7721, B16, SGC-7901, A549, KB, HL-60). Most compounds exhibited potent antiproliferative effects with low micromolar

Synthesis, computational study and cytotoxicity of 4-hydroxycoumarin-derived imines/enamines.

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Ingia / Ingia

In this study, we applied a direct condensation between 3-acetyl-4-hydroxy-2H-chromen-2-one and different amines (anilines and benzyl amines) in order to synthesize some coumarin-based imines/enamines (3a-o) as cytotoxic agents. All the compounds were characterized by means of FT-IR, NMR, mass

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Herbal & Natural Medicine

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