chronic traumatic encephalopathy/protease

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NakalaMajaribio ya klinikiHati miliki

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3 matokeo

Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury.

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Ingia / Ingia

Transactivation response DNA-binding protein 43 (TDP-43) proteinopathy has recently been reported in chronic traumatic encephalopathy, a neurodegenerative condition linked to prior history of traumatic brain injury (TBI). While TDP-43 appears to be vulnerable to proteolytic modifications under

Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment

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Ingia / Ingia

Repeated concussion represents a serious health problem as it can result in various brain pathologies, ranging from minor focal tissue injury to severe chronic traumatic encephalopathy. The calcium-dependent protease, calpain, participates in the development of neurodegeneration following

Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease.

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Ingia / Ingia

Alzheimer disease (AD) and chronic traumatic encephalopathy (CTE) involve the abnormal accumulation in the brain of filaments composed of both three-repeat (3R) and four-repeat (4R) (3R/4R) tau isoforms. To probe the molecular basis for AD's tau filament propagation and to improve detection of tau

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Herbal & Natural Medicine

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