distamycin/atrophy

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NakalaMajaribio ya klinikiHati miliki

Chagua aina ya aina

2 matokeo

DNA binding properties of FCE24517, an electrophilic distamycin analogue.

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Ingia / Ingia

The distamycin derivative FCE24517 binds both reversibly and irreversibly to DNA. At 37 degrees C, the drug originates reversible complexes that are strong enough to survive to the electrophoretic separation of the substrate. These complexes slowly evolve to covalent adducts (10(-4) adducts/bp/h)

Novel DNA photocleaving agents with high DNA sequence specificity related to the antibiotic bleomycin A2.

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Ingia / Ingia

We have designed and synthesized a series of novel DNA photocleaving agents which break DNA with high sequence specificity. These compounds contain the non-diffusible photoactive p-nitrobenzoyl group covalently linked via a dimethylene (or tetramethylene) spacer to thiazole analogues of the DNA

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Herbal & Natural Medicine

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