distamycin/sarcoma

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NakalaMajaribio ya klinikiHati miliki

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9 matokeo

Antiangiogenic, antitumoural and antimetastatic effects of two distamycin A derivatives with anti-HIV-1 Tat activity in a Kaposi's sarcoma-like murine model.

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Ingia / Ingia

The antiangiogenic, antitumoural and antimetastatic effects of two novel sulphonic derivatives of distamycin A, PNU145156E and PNU153429, were studied in a Kaposi's sarcoma-like tumour model obtained by injecting nude mice with cells releasing extracellular HIV-Tat protein, derived from a tumour

Rifampicin and distamycin A as inhibitors of Rous sarcoma virus reverse transcriptase.

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Ingia / Ingia

Effect of distamycin A and congocidine on DNA synthesis by rous sarcoma virus reverse transcriptase.

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Ingia / Ingia

[Action of distamycin A and its derivatives on the Moloney murine sarcoma virus in vitro and in vivo].

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Ingia / Ingia

[The effect of rifampicin and distamycin A on DNA synthesis by RNA-dependent DNA polymerases of Rous sarcoma virus].

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Ingia / Ingia

Synthesis, DNA binding and antiviral activity of distamycin analogues containing different heterocyclic moieties.

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Ingia / Ingia

A series of novel distamycin analogues possessing an additional benzene or heterocyclic ring have been synthesised and tested for selective DNA binding properties and antiviral activity. Inhibition of herpes virus in cell culture appears to be related to AT base pair specificity. Some of the new

Inhibition of telomerase activity by a distamycin derivative: effects on cell proliferation and induction of apoptosis in human cancer cells.

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Ingia / Ingia

In this study, we evaluated the potential of the distamycin derivative MEN 10716 as a telomerase inhibitor. Exposure of human melanoma cell extracts to MEN 10716 induced a dose-dependent inhibition of telomerase activity, with an IC50 of 24+/-3 microM. When intact JR8 melanoma cells were chronically

Endothelial cells overexpressing basic fibroblast growth factor (FGF-2) induce vascular tumors in immunodeficient mice.

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Ingia / Ingia

Basic fibroblast growth factor (FGF-2) is expressed in vascular endothelium during tumor neovascularization and angioproliferative diseases, including vascular tumors and Kaposi's sarcoma (KS). We have investigated the in vivo biological consequences of endothelial cell activation by endogenous

Combination of the new minor groove alkylator tallimustine and melphalan.

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Ingia / Ingia

The benzoyl nitrogen mustard derivative of distamycin A, tallimustine, belongs to a new class of alkylating agents, known as DNA minor groove alkylating agents. It alkylates adenine N3 with high sequence specificity, causing no alkylation of guanine N7, the main site of alkylation of clinically used

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Herbal & Natural Medicine

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