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eburnamonine/cerebral infarction

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NakalaMajaribio ya klinikiHati miliki
5 matokeo

[Open clinical trial with (-)eburnamonine in patients suffering from cerebral ischemia].

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Ingia / Ingia

Medical therapy of cerebral ischemia. Vasoactive and eumetabolic therapy.

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Ingia / Ingia
After briefly evaluating the contraindications and indications of vasoactive and eumetabolic therapy of cerebral ischemia, the paper considers the main drugs at present in use in therapy of the syndrome induced by diffused cerebral arteriosclerosis. Among the drugs with a mainly vasoactive effect,

Retinal angiography in the study of cerebral ischemia.

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Ingia / Ingia
On the basis of the assumption of an affinity between cerebral and retinal vessels, it was sought to demonstrate that the variations induced in the retinal circulation are akin to those occurring at the cerebral level. The technique of retinal fluorescein angiography was used to evaluate the

Protective effects of vinpocetine and structurally related drugs on the lethal consequences of hypoxia in mice.

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Ingia / Ingia
Vinpocetine has been compared with 3 structurally related drugs for activity in protecting mice from hypoxia-induced lethality upon i.p. administration. In order of potency, vinpocetine (ED50 = 16.6 mg/kg), 1-eburnamonine (ED50 = 21.0 mg/kg), vinconate (ED50 approximately 25 mg/kg), and vincamine
The effects of a new eburnamenine derivative (3 beta,14 alpha, 16 alpha)-(+/-)-14,15-dihydro-20,21-dinoreburnamenin-14-ol (vindeburnol, RU 24722) on EEG, on brain energy metabolism and on local cerebral blood flow (LCBF) and in different experimental models of cerebral insufficiency were compared
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