The present invention is a method of treating mammals for alleviating inflammation by utilization of a non-steroid topical agent. The agent is ethyl linoleate [ethyl-cis,cis(9,12)-octadecadienoate] which may be combined in a preferred formulation with one or more antioxidants such as .alpha.-tocopherol, d,l-histidine, and tertiary butyl hydroquinone; a stabilizer such as Tween-80; and inert esters such as ethyl oleate, ethyl palmitate, and ethyl stearate. The agent is applied in a therapeutic dosage range of 0.2-0.8 mg/cm.sup.2 of body surface both internal and external, with a preferred dosage of 0.5 mg/cm.sup.2. This topical remedy for inflammation for internal and external body surfaces is utilized principally in a single dose but may be utilized in multiple doses are required due to low toxicity (60:1). Among the conditions with inflammatory responses amenable to treatment are ultraviolet ratiation, solar radiation, non-infectious conjunctivitis, hemorrhoids (acute), abrasions, ingrown finger or toenail (granulation), skin graft donor sites, vaginitis, poison ivy, psoriasis, herpes simplex (cold sores, aphthous ulcers), pruritis ani/cruri, chemical inflammation, and insect stings/bites.

Non-steroid topical agent for alleviating inflammation in mammals

Agents selected from: (i) a C.sub.1-C.sub.24 alkyl ester of a saturated or cis-unsaturated C.sub.10-C.sub.24 fatty acid; (ii) a monoester or polyester of a polyol having at least four hydroxy groups with a saturated or cis-unsaturated C.sub.10-C.sub.24 fatty acid or an anhydro derivative thereof; (iii) a monoester or polyester of a mono-, di- or poly-saccharide with a saturated or cis-unsaturated C.sub.10-C.sub.24 fatty acid; (iv) an amide of a saturated or cis-unsaturated C.sub.10-C.sub.24 fatty acid with an aliphatic or aromatic amine or with an amino acid, peptide, protein or aminosaccharide; and (v) combinations of any of (i) to (iv), can be used for treatment of autoimmune diseases and other immune-associated inflammatory disorders. Preferred agents are ethyl oleate and mannide monooleate or a combination thereof.

ethyl oleate/inflammation

Non-steroid topical agent for alleviating inflammation in mammals

Use of esters of long-chain fatty acids for treatment of autoimmune diseases

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