fostriecin/kichefuchefu

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NakalaMajaribio ya klinikiHati miliki

Chagua aina ya aina

2 matokeo

Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin.

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Ingia / Ingia

We conducted a phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. Fostriecin was administered intravenously over 60 min on days 1-5 at 4-week intervals. Dose was escalated from 2 mg m(-2) day(-1) to 20 mg m(-2) day(-1) in 20 patients. Drug pharmacokinetics was

Phase I and pharmacokinetic study of fostriecin given as an intravenous bolus daily for five consecutive days.

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Ingia / Ingia

Fostriecin (CI-920) is a potent inhibitor of protein phosphatase 2A (PP2A) and protein phosphatase 4(PP4) found to have anticancer activity in preclinical testing. A phase I study was conducted to evaluate the maximum-tolerated dose (MTD), toxicity profile, and pharmacokinetics (PK) of this drug.

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Herbal & Natural Medicine

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