fostriecin/saratani ya mapafu

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NakalaMajaribio ya klinikiHati miliki

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3 matokeo

Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin.

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Ingia / Ingia

We conducted a phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. Fostriecin was administered intravenously over 60 min on days 1-5 at 4-week intervals. Dose was escalated from 2 mg m(-2) day(-1) to 20 mg m(-2) day(-1) in 20 patients. Drug pharmacokinetics was

In vitro activity of the novel antitumor antibiotic fostriecin (CI-920) in a human tumor cloning assay.

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Ingia / Ingia

A human tumor cloning assay was utilized to evaluate the antineoplastic activity of the novel antitumor antibiotic fostriecin (CI-920). Initial screening with 10.0 mcg/ml continuous exposure against a variety of histologic tumor types resulted in 14/51 (27%) in vitro responses (defined as greater

Determination of fostriecin pharmacokinetics in plasma using high-pressure liquid chromatography assay.

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Ingia / Ingia

Fostriecin is an antitumor antibiotic with marked activity against ovarian, breast, and lung cancer cell lines in the human tumor clonogenic assay. The mechanism of cytotoxicity in vivo is unknown; in vitro it has been shown to inhibit macromolecular synthesis, interact with the reduced folate

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Herbal & Natural Medicine

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Tafuta mimea ya dawa na athari zao
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