gelonium multiflorum/saratani

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In-vitro antitumor-activity of the plant ribosome-inactivating proteins map-30 and gap-31.

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Ingia / Ingia

MAP 30 and GAP 31 are plant proteins isolated from Momordica charantia and Gelonium multiflorum, respectively. They have recently been shown to inhibit HIV-1 infection and replication. These proteins also possess a novel DNA topoisomerase-poison-like activity as well as ribosome inactivation. They

Inhibition of MDA-MB-231 human breast tumor xenografts and HER2 expression by anti-tumor agents GAP31 and MAP30.

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Ingia / Ingia

GAP31 (Gelonium protein of 31 kDa) and MAP30 (Momordica protein of 30 kDa) are agents isolated from the medicinal plants Gelonium multiflorum and Momordica charantia, respectively. The current study was conducted to investigate the efficacy of GAP31 and MAP30 on estrogen-independent and highly

A Spectroscopic Study on Secondary Structure and Thermal Unfolding of the Plant Toxin Gelonin Confirms Some Typical Structural Characteristics and Unravels the Sequence of Thermal Unfolding Events.

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Ingia / Ingia

Gelonin from the Indian plant Gelonium multiflorum belongs to the type I ribosome-inactivating proteins (RIPs). Like other members of RIPs, this toxin glycoprotein inhibits protein synthesis of eukaryotic cells; hence, it is largely used in the construction of immunotoxins composed of

Crystallization and preliminary X-ray analysis of GAP 31. A protein which inhibits the life cycle of HIV-1.

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Ingia / Ingia

GAP 31 is an anti-HIV plant protein that we have identified and purified to homogeneity from Gelonium multiflorum. It is the first reported example of an anti-HIV agent capable of acting against multiple stages of the viral life cycle, on viral infection and viral replication. GAP 31 is a unique

GAP31 from an ancient medicinal plant exhibits anti-viral activity through targeting to Epstein-Barr virus nuclear antigen 1.

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Ingia / Ingia

Since it was discovered as the first human tumor virus in 1964, Epstein-Barr Virus (EBV) is now implicated in several types of malignancies. Accordingly, certain aspects of EBV pathobiology have shown promise in anti-cancer research in developing virus-targeting methods for EBV-associated cancers.

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Herbal & Natural Medicine

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