giant cell tumor of bone/tyrosine

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NakalaMajaribio ya klinikiHati miliki

Chagua aina ya aina

6 matokeo

Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

BACKGROUND Giant cell tumors (GCTs) of bone are primary benign bone tumors that are characterized by a high number of osteoclast-like multinuclear giant cells (MNCs). Recent studies suggest that the spindle-shaped stromal cells in GCTs are tumor cells, while monocyte-like cells and MNCs are reactive

Purification and characterization of a novel tyrosyl-aminopeptidase from human osteoclastomas.

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Ingia / Ingia

1. An aminopeptidase that preferentially releases tyrosine residues from synthetic substrates has been purified from human osteoclastomas. This enzyme also hydrolyses dipeptides having an N-terminal tyrosine and a hydrophobic carboxy-terminal amino acid. 2. The tyrosyl-aminopeptidase consists of two

The expression of Met/hepatocyte growth factor receptor gene in giant cell tumors of bone and other benign musculoskeletal tumors.

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Ingia / Ingia

Overexpression of the hepatocyte growth factor receptor (Met/HGF receptor), a transmembrane tyrosine kinase encoded by the MET proto-oncogene, is involved in transformation and invasive behavior of human carcinomas and sarcomas. We have previously found that bone sarcomas express high levels of

Histomorphometric and immunocytochemical studies of src-related osteopetrosis.

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Ingia / Ingia

"Knockout" of the src proto-oncogene in mice resulted in the unexpected development of osteopetrosis which was shown subsequently in 4-6 week old src-mutants to be due to failure of src-mutant osteoclasts to form ruffled borders. Histomorphometric analysis of vertebrae and humeri from 9-10 month old

Current Molecular Targeted Therapies for Bone and Soft Tissue Sarcomas.

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Ingia / Ingia

Systemic treatment options for bone and soft tissue sarcomas remained unchanged until the 2000s. These cancers presented challenges in new drug development partly because of their rarity and heterogeneity. Many new molecular targeting drugs have been tried in the 2010s, and some were approved for

Dedifferentiated chondrosarcoma mimicking a giant cell tumor. Is this low grade dedifferentiated chondrosarcoma?

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Ingia / Ingia

We report a very rare case of a dedifferentiated chondrosarcoma mimicking a benign giant cell tumor. A 22-year-old male was admitted to our hospital with a history of mild left wrist pain after a skiing trauma. Radiology revealed an extensive meta-epiphyseal osteolytic lesion in the distal ulna,

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Herbal & Natural Medicine

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