glabrol/glycyrrhiza

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Biosynthesis of the dimethylallyl moiety of glabrol in Glycyrrhiza glabra hairy root cultures via a non-mevalonate pathway.

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Ingia / Ingia

Incorporation of [1-13C]glucose indicates that the biosynthesis of the hemiterpene moiety of glabrol, the main prenylated flavanone in the hairy root cultures of Glycyrrhiza glabra, proceeds via a glyceraldehyde/pyruvate non-mevalonate pathway.

Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol.

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Ingia / Ingia

Licorice (Glycyrrhiza glabra, GG) is one of the most frequently used herbal medicines worldwide, and its various biological activities have been widely studied. GG is reported to have neurological properties such as antidepressant, anxiolytic, and anticonvulsant effects. However, its hypnotic

Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.

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Ingia / Ingia

Licorice shows a variety of pharmacological activities. This work aims to discover bioactive natural products from one botanical source of licorice, Glycyrrhiza inflata. A total of 67 free phenolics were isolated to form a compound library. Based on the bioactivities of licorice, these compounds

[Chemical constituents of the roots of Glycyrrhiza eurycarpa P.C.Li].

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Ingia / Ingia

Four compounds were isolated from the roots of Glycyrrhiza eurycarpa. They were identified as licochalcone A, glabrol, betulic acid and beta-sitosterol by chemical and physical properties and spectral analysis.

Antimicrobial agents from higher plants. Antimicrobial isoflavanoids and related substances from Glycyrrhiza glabra L. var. typica.

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Ingia / Ingia

Bioassay-directed fractionation of Glycyrrhiza glabra L. var. typica resulted in the isolation and characterization of glabridin (I), glabrol (2), glabrene (3), 3-hydroxyglabrol (4), 4'-O-methylglabridin (5), 3'-methoxyglabridin (6), formononetin (7), phaseollinisoflavan (8), hispaglabridin A (9),

In-vitro antitumor activity of compounds from Glycyrrhiza glabra against C6 glioma cancer cells: identification of natural lead for further evaluation

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Ingia / Ingia

A HP20 resin-based unique method was adopted to get an active fraction of the hydroalcoholic extract of G. glabra roots. The fraction showed potent cytotoxicity against cancer cell line and was further subjected to detailed phytochemical investigation to obtain ten biomarkers. The isolated

Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme.

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Ingia / Ingia

The development of multi-drug resistance to existing anticancer drugs is one of the major challenges in cancer treatment. The over-expression of cytochrome P450 1B1 enzyme has been reported to cause resistance to cisplatin. With an objective to discover cisplatin-resistance reversal agents, herein,

Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity.

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Ingia / Ingia

Bioassay-guided fractionation of the EtOH extract of licorice (Glycyrrhiza glabra roots), using a GAL-4-PPAR-gamma chimera assay method, resulted in the isolation of 39 phenolics, including 10 new compounds (1-10). The structures of the new compounds were determined by analysis of their

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Herbal & Natural Medicine

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