histiocytic sarcoma/phosphatase

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Estimation of neutrophil alkaline phosphatase in malignant histiocytosis.

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Ingia / Ingia

Canine histiocytic sarcoma cell lines with SHP2 p.Glu76Gln or p.Glu76Ala mutations are sensitive to allosteric SHP2 inhibitor SHP099.

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Ingia / Ingia

Some canine cases of histiocytic sarcoma (HS) carry an activating mutation in the src homology two domain-containing phosphatase 2 (SHP2) encoded by PTPN11. SHP099 is an allosteric inhibitor of SHP2 that stabilizes SHP2 in a folded, auto-inhibited conformation. Here, we examined the expression and

Macrophage-like cell line (HS-P) from a rat histiocytic sarcoma.

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Ingia / Ingia

With future exploration of macrophage properties in mind, we established a novel cell line (HS-P) from a transplantable histiocytic sarcoma, derived originally from a tumour in an aged F344 rat. HS-P was subjected to 70 serial passages, in which the mean doubling time was 15.7 h. The cells, which

Malignant lymphoma of true histiocytic origin: histiocytic sarcoma. A morphological, ultrastructural, immunological, cytochemical and clinical study of 10 cases.

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Ingia / Ingia

Ten tumors of true histiocytic origin (Histiocytic Sarcoma) are presented. The tumor cells were identified as histiocytes by immunological, cytochemical and ultrastructural criteria (cytoplasmic lysozyme activity, presence of C3 and Fc gamma receptor, strong acid phosphatase and alpha-naphthyl

Malignant histiocytosis (histiocytic sarcoma). A (the?) major cause of the 'midline granuloma syndrome'.

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Ingia / Ingia

Five out of eight consecutive cases with initial symptoms of a 'midline granuloma' were identified as malignant histiocytosis (histiocytic sarcoma) which within 5 months to 4 years led to generalization and death. The three remaining cases also fulfilled the morphological criteria of this type of

Morphological characteristics of a transplantable histiocytic sarcoma (HS-J) in F344 rats and appearance of renal tubular hyaline droplets in HS-J-bearing rats.

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Ingia / Ingia

A transplantable tumour (HS-J) was established from a spontaneous histiocytic sarcoma found in a 24-month-old male F344 rat. Serial transplantations (seven generations) were made in syngeneic male and female rats by means of intraperitoneal or subcutaneous implants, with a 100% take rate. Rats given

Malignant histiocytosis: a clinical, histologic, and immunohistochemical study of 20 cases.

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Ingia / Ingia

To better characterize the diagnostic criteria and clinical behavior of malignant histiocytosis, 20 patients treated at the Mayo Clinic during a 25-year period were studied. A wide spectrum of cytologic differentiation was observed, with cells ranging from bland to highly anaplastic;

DEL cell line: a "malignant histiocytosis" CD30+ t(5;6)(q35;p21) cell line.

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Ingia / Ingia

A new cell line DEL, established in vitro, was isolated from a pleural effusion of a boy who died of malignant histiocytosis. Its principal characteristics are: strong positivity with monoclonal antibodies (MAbs) to CD25, CD30, CD45R, KiM7, EMA, HLA Cl I and II; constant presence of acid

Leukemic phase of malignant histiocytosis (arguments in favour of the histiomonocytic origin of the abnormal cells).

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Ingia / Ingia

A 15-year-old female was treated for malignant histiocytosis. The occurrence of a leukemic phase (178,000 blasts/cu mm) during the follow up provided the opportunity of studying a large number of malignant cells by cytochemical electron microscopic, and cell membrane markers techniques. Acid

Malignant histiocytosis of the intestine: report of three cases with immunological and cytochemical analysis.

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Ingia / Ingia

Tumour cells from three cases of malignant histiocytosis of the intestine (MHI) have been studied immunologically and cytochemically. The cells did not form E rosettes and showed weak Fc gamma surface receptors. They contained non-specific esterase and acid phosphatase in diffuse granular

Malignant histiocytosis: A light- and electron-microscopic and histochemical study.

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Ingia / Ingia

The light- and electron-microscopic features and histochemical characterization of three consecutive cases of malignant histiocytosis (MH) are reported. Each case demonstrated involvement of lymph nodes and bone marrow. In the lymph node, the characteristic destructive sinusoidal pattern of

Cytological and functional characterization of three cases of malignant histiocytosis.

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Ingia / Ingia

This report is a cytological and functional description of 3 cases of malignant histiocytosis (MH). These patients suffered from an intense proliferation of histiocytic cells that occurred predominantly in the bone marrow in 2 cases (the primitive cell type of MH), and in the spleen, liver and

Malignant histiocytosis (true histiocytic lymphoma) clinicopathological study of 25 cases.

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Ingia / Ingia

Twenty-five cases originally diagnosed as malignant histiocytosis/true histiocytic lymphoma were reviewed according to both pathological and clinical criteria. Microscopically, they were characterized by large, pleomorphic tumour cells showing variable degrees of atypia and phagocytic activity. The

Malignant histiocytosis. Immunohistochemical characterization on paraffin embedded tissue.

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Ingia / Ingia

Clinically, malignant histiocytosis is a malignant neoplasia with poor prognosis. Diseased are lymphnodes (especially cervical nodes), liver, spleen and bones. Few cases become leukemic. The cells show characteristic pale roundish, often indented nuclei, without large nucleoli and with abundant

Malignant histiocytosis and related tumors. A clinicopathologic study of 42 cases using cytological, histochemical and ultrastructural parameters.

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Ingia / Ingia

Light and electron microscopical, immunohistochemical and clinical characteristics in 42 cases of malignant neoplasms, arising from true histiocytes, are described. These were separated in a lymphoma-like subtype, called true histiocytic lymphoma (29 patients) and a disseminated variant, called

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