hymenoxon/hymenoxys

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Hymenoxon, a poisonous sesquiterpene lactone from Hymenoxys odorata DC. (bitterweed).

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Ingia / Ingia

Hymenoxon (C15H22O5) was isolated from Hymenoxys odorata DC. in 0.5% yield. The structure of hymenoxon is shown to be 1. The intraperitoneal LD50 of hymenoxon in sheep is about 7 mg/kg.

Alkylation of deoxyguanosine by the sesquiterpene lactone hymenoxon.

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Ingia / Ingia

Hymenoxon, a toxic sesquiterpene lactone found in the ruminant forage plant Hymenoxys odorata, binds deoxyguanosine in a cell-free system, and forms adducted guanine residues in sheep lymphocyte DNA. Mitogen-stimulated DNA synthesis in lymphocytes was inhibited by hymenoxon at concentrations greater

Acute exposure to hymenoxon: electron microscopic study of the mouse liver.

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Ingia / Ingia

Young, male mice (25 to 30 g) were given oral doses of hymenoxon, a sesquiterpene lactone, for 5, 10, or 20 days. Hymenoxon, isolated from Hymenoxys odorata DC, was dissolved in dimethyl sulfoxide (DMSO) and water (1:1, v/v) and was administered daily at a dosage level of 100 mg/kg of body weight

Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin.

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Ingia / Ingia

Hymenoxon and helenalin are toxic sesquiterpene lactones present in the toxic range plants Hymenoxys odorata and Helenium microcephalum. Helenalin (25 mg/kg) or hymenoxon (30 mg/kg) administered to immature male ICR mice caused a rapid decrease in hepatic glutathione levels and were lethally toxic

Ovine urinary metabolites of hymenoxon, a toxic sesquiterpene lactone isolated from Hymenoxys odorata DC.

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Ingia / Ingia

Protective effects of antioxidants on bitterweed (Hymenoxys odorata DC) toxicity in sheep.

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Ingia / Ingia

Antidotal effects of the 2 antioxidants butylated hydroxyanisole (BHA) and ethoxyquin (EQ) were evaluated in bitterweed (Hymenoxys odorata DC) toxicosis in sheep. Bitteerweed contains a toxic sesquiterpene lactone, hymenoxon, the toxicity of which is reduced by cysteine. Both BHA and EQ are known to

Experimental prevention of bitterweed (Hymenoxys odorata) poisoning of sheep.

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Ingia / Ingia

To examine the effects on bitterweed toxicity of dietary factors known to increase thiol concentrations in the body, 36 lambs were fed one of the following diets (12 lambs/diet) for a minimum of 9 days prior to bitterweed administration: diet 1, 10% crude protein; diet 2, 20% crude protein, 0.5%

The effect of dietary supplements on chronic bitterweed (Hymenoxys odorata) poisoning in sheep.

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Ingia / Ingia

Two experiments were designed to establish a chronic bitterweed dose in sheep and to study the prevention of chronic bitterweed poisoning with dietary supplements of high protein (20% crude protein) and sodium sulfate. The first experiment consisted of 5 lambs in each of 3 groups. The low dose

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