koetjapic acid/sandoricum

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Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells.

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Ingia / Ingia

Deregulated cell signaling pathways result in cancer development. More than one signal transduction pathway is involved in colorectal cancer pathogenesis and progression. Koetjapic acid (KA) is a naturally occurring seco-A-ring oleanene triterpene isolated from the Sandoricum koetjape stem bark. We

Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr.

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Ingia / Ingia

BACKGROUND Angiogenesis, the formation of new blood vessels, has become an important target in cancer therapy. Angiogenesis plays an important role in tumor growth and metastasis. Koetjapic acid (KA) is a seco-A-ring oleanene triterpene isolated from S. koetjape. The solvent extract of this plant

Ichthyotoxic and anticarcinogenic effects of triterpenoids from Sandoricum koetjape bark.

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Ingia / Ingia

After bioassay-guided fractionation of the extract from Sandoricum koetjape bark, which exhibited significant toxicity to killifish (Oryzias latipes), two ichthyotoxic triterpenoids were isolated and characterized as koetjapic acid and 3-oxo-olean-12-en-29-oic acid. These constituents, along with

Plant anticancer agents, L. cytotoxic triterpenes from Sandoricum koetjape stems.

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Ingia / Ingia

A new ring-A secotriterpene, koetjapic acid [1], and five known compounds, 3-oxo-olean-12-en-29-oic acid [2] (a novel natural product), katonic acid [3], (-)-alloaromadendrene, (-)-caryophyllene oxide, and (+)-spathulenol, have been isolated and characterized from a cytotoxic Et2O-soluble extract of

Pharmacokinetics and antiangiogenic studies of potassium koetjapate in rats

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Ingia / Ingia

Purpose: Koetjapic acid is an active compound of a traditional medicinal plant, Sandoricum koetjape. Although koetjapic acid has a promising anticancer potential, yet it is highly insoluble in aqueous solutions. To increase aqueous

Increased aqueous solubility and proapoptotic activity of potassium koetjapate against human colorectal cancer cells.

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Ingia / Ingia

OBJECTIVE Recently, we have isolated koetjapic acid (KA) from Sandoricum koetjape and identified its selective anticancer potentiality against colorectal carcinoma. KA is quite likely to be useful as a systemic anticancer agent against colorectal malignancy. However, with extremely low solubility,

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Herbal & Natural Medicine

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