laser trilobum/lactone

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Trilobolide and related sesquiterpene lactones from Laser trilobum possessing immunobiological properties.

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Ingia / Ingia

Three new and five known sesquiterpene lactones were isolated from the roots of Laser trilobum (L.) Borkh. Chemical identity of the known compounds and structural analysis of the new ones were determined by HR MS and NMR spectroscopy. The two new sesquiterpene lactones: 2-acetoxytrilobolide and

Sesquiterpene lactone trilobolide activates production of interferon-γ and nitric oxide.

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Ingia / Ingia

Trilobolide (TB), a sesquiterpene lactone isolated from Laser trilobum is an inhibitor of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA). We have found that upon the in vitro exposure to TB, rodent peritoneal cells and human peripheral blood mononuclear cells secrete high amounts of IFN-γ. The

Immunobiological properties of sesquiterpene lactones obtained by chemically transformed structural modifications of trilobolide.

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Ingia / Ingia

Our previous research on immunostimulatory properties of trilobolide and its structurally related natural analogues isolated from Laser trilobum (L.) Borkh., encouraged us to investigate structurally related guaianolides belonging to a specific group of sesquiterpene lactones with characteristic

Phytochemistry of the genus Thapsia.

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Ingia / Ingia

In a chemotaxonomic study of the genus Thapsia (Apiaceae), root material of five taxa has been analysed for skin irritating sesquiterpene lactones and the coumarins, 6-methoxy-7-geranyloxycoumarin and scopoletin. Eight tetraesters of 2, 3, 7, 8, 10, 11-hexahydroxy-C (6)-guaianolide and two triesters

Immunoassay for determination of trilobolide.

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Ingia / Ingia

Trilobolide (Tb) is a pharmacologically interesting sesquiterpene lactone isolated from Laser trilobum (L.) Borkh. Structural relation to a sarco/endoplasmic reticulum Ca2+-ATPase inhibitor thapsigargin bring promising prospects for Tb to be used in the development of new anti-cancer drugs. As long

Trilobolide-porphyrin conjugates: on synthesis and biological effects evaluation.

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Ingia / Ingia

Trilobolide (Tb), a potent natural counterpart of thapsigargin, is a sesquiterpene lactone of guaianolide type isolated from horse caraway (Laser trilobum, L. Borkh). Tb exerts remarkable pharmacological properties based on irreversible inhibition of sarco/endoplasmic reticulum calcium ATPase

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Herbal & Natural Medicine

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