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Livestock and aquaculture production is under political and social pressure, especially in the European Union (EU), to decrease pollution and environmental damage arising due to animal agriculture. The EU has banned the use of antibiotics and other chemicals, which have been shown to be effective in
The effect of the addition of 50% human or mouse serum on the antibacterial activity of cefonicid, three first generation cephalosporins and ampicillin was studied. Human serum added to the test system considerably reduced the activity of cefonicid against Staphylococcus aureus and Staphylococcus
Antibacterial activity of ZnO nanoparticles (NPs) triggered by generation of reactive oxygen species (ROS) depends on the fate of photoexcited charge carriers. Batches of wide band gap ZnO NPs of 7-9nm sizes, capped with polyethylene glycol (PEG), ascorbic acid (AsA), mercaptoacetic acid (MAA) and
In southern Africa, the roots of Schotia brachypetala are used by traditional healers to treat dysentery and diarrhoea. Activity-directed fractionation of the ethanol extract of the dried leaves yielded 9,12,15-octadecatrienoic (linolenic) acid and methyl-5,11,14,17-eicosatetraenoate. These fatty
Transport of natural peptides and antibacterial phosphonopeptide analogues was studied in Streptococcus faecalis ATCC 9790. Competition studies, and the isolation of peptide-transport deficient mutants, indicate the presence of two peptide permeases. One is a high-rate system used by dipeptides, and
BACKGROUND
This study assessed the photochemical fate of nine sulfonamides (sulfamerazine, sulfanilamide, sulfamethoxypyridazine, sulfamethoxazole, sulfachloropyridazine, sulfamethazine, sulfadiazine, sulfathiazole and sulfadimethoxine) during a 6h irradiation period with UVA/UVB-light and UVA-light
Serum from the horseshoe crab, Limulus polyphemus, was examined for bactericidal activity against five species of bacteria. Greatest activity was found against Pseudomonas putida and Flavobacterium sp.; with the former, serum dilutions as high as 1:20 were capable of reducing viable counts by 50%
The activity of ten 4-quinolone drugs was tested against five Escherichia coli mutants. Mutational resistance was found to reduce the activity of all ten drugs, indicating that they display biochemical cross-resistance with each other. However, ciprofloxacin and, to a lesser extent, ofloxacin and
Determination of the antibacterial action of serum and the cerebrospinal fluid (CSF) is an excellent method for controlling the efficiency of antibioticotherapy in severe bacterial infections such as septicemia, endocarditis, meningitis. The author studied comparatively two methods for determining
In the last few decades, a lot of work has been done on heterocycles, especially the imidazole ring, to obtain a scaffold with potential pharmacological properties such as antibacterial, antifungal, anticancer, antiviral, antidiabetic and others, with lesser side effects. The search for new
Sch 34343 inhibited 50% of the 105 bacterial strains tested at concentrations ranging from less than 1.25 to 5.0 mg/l and 90% at 5.0 to 10.0 mg/l. Against Escherichia coli and Klebsiella pneumoniae strains with cefotaxime MICs greater than 5.0 mg/l, 1.0-4.0 mg/l of Sch 34343 was required for
We have studied the action of various antimicrobial agents in microbiological media and in human duodeno-pancreatic secretions. In the latter medium, clioquinol exhibited a rapid bactericidal effect on both growing and stationary bacteria at concentrations near its MIC. However, it was merely