Ukurasa 1 kutoka 117 matokeo
Literature on the relationship of cannabis use and cognition in schizophrenia provides the paradoxical view that cannabis use is sometimes linked with less severe impairment in neurocognition. This paper explored the possibility that this is a reflection of a dose related response between lifetime
We have detected the presence of a specific [3H] CP 55,940 binder in the cytosol of rat cerebral cortex. Competition studies showed that only cold CP 55,940 and to a lesser extent delta9THC was able to compete with [3H] CP 55,940; little competition was observed with either delta8THC or anandamide.
BACKGROUND
Cannabis use is associated with psychosis and a range of subclinical psychiatric symptoms. The strength of this association depends on dosage and age at first use. The current study investigates whether level of cannabis exposure and starting age are associated with specific profiles of
This study, based on data (N = 134) obtained by self-administered questionnaires, examines the extent marijuana users can be sexually differentiated regarding usage patterns, acquisition, distribution, effects on social relationships, and other activities. Generally, no significant sexual variations
The present study was designed to test the possible existence of changes in brain cannabinoid receptors in morphine-dependent mice. To this end, we compared cannabinoid receptor binding and WIN 55,212-2-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate ([35S]GTP gamma S) binding in several
The analysis of synthetic cannabinoid compounds in a urine sample is currently one of the more complex tasks facing toxicologists. The list of prevalent compounds in circulation at any given time is constantly in flux, changing at a rapid rate to avoid legal control and to a lesser extent to avoid
OBJECTIVE
The factor structure of DSM-IV substance disorder criteria is examined among alcohol, cannabis, cocaine and opiate users to determine the dimensionality of abuse and dependence criteria within each of these drug classes and whether a common construct can be generalized across drug
We examined the prevalence of 20 individual symptoms of cannabis withdrawal in the U.S. general population. More than 29% of past 12-month cannabis users reported experiencing at least two cannabis withdrawal symptoms, with 8% reporting impairment from at least two symptoms or withdrawal relief. The
To examine community/racial differences in adolescent marijuana use and the variations in factors underlying the observed differences, a questionnaire survey study was conducted with 9th to 12th graders (n = 1,936) from two communities in New Jersey. Marijuana use was significantly higher among
Recent studies have elucidated the biosynthetic pathway of cannabinoids and have highlighted the preference for a C-3 n-pentyl side chain in the most prominently represented cannabinoids from Cannabis sativa and their medicinally important decarboxylation products. The corresponding C-3 n-propyl
Most cannabinoid 1 receptor (CB1R) agonists will signal through both G protein-dependent and -independent pathways in an unbiased manner. Recruitment of β-arrestin 2 desensitizes and internalizes receptors, producing tolerance that limits therapeutic utility of cannabinoids for
Cannabis and, to a lesser extent, synthetic cannabinoids are used during adolescence, a period in which multiple brain areas are still undergoing development. Among such areas is the hypothalamus, which is implicated in the control of sleep-wake cycle. In the present report, we show that exposing
Although the endocannabinoid system (ECS) is involved in the regulation of several physiological processes, including sleep and the immune response, its role during infections has not been fully studied. It is well known that the use of this drug increases susceptibility to infections because of the
The usage of marijuana and its legalization has been growing rapidly, being abused by a wide range of age groups. Its effects on the heart are well known, but coronary artery vasospasm causing ST elevation myocardial infarction (STEMI) from Marijuana alone is rather lesser known. Herein, we report a
OBJECTIVE
To study the ocular hypotensive effect of a nonpsychotropic cannabinoid, HU-211 (11 -hydroxy-delta8-tetra-hydrocannabinol, dimethylheptyl), an N-methyl-D-aspartate (NMDA) agonist, in normotensive rabbits.
METHODS
The cannabinoid HU-211, being lipophilic, was incorporated into a stable