lesser/scopolamine

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Methamphetamine plus scopolamine potentiates behavioral sensitization and conditioning.

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Ingia / Ingia

The effects of repeated methamphetamine (4.0 mg/kg) plus scopolamine (0.5 mg/kg) treatment on behavioral sensitization and drug conditioning in rats were compared with the effects of repeated methamphetamine treatment. Behavioral sensitization induced by repeated methamphetamine plus scopolamine

Scopolamine blocks olfaction-induced fast waves but not olfactory evoked potentials in the dentate gyrus.

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Ingia / Ingia

The presentation of some odorous materials such as xylene or toluene under the snout of rats has been shown to elicit 15-30 Hz fast-wave bursts in both the olfactory bulb and dentate gyrus. Electrical stimulation of the olfactory bulb elicits an evoked potential (latency of first peak is 16-18 ms)

Acute and chronic arecoline: effects on a scopolamine-induced deficit in complex maze learning.

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Ingia / Ingia

These studies tested the effect of arecoline, a nonselective muscarinic agonist, administered either acutely or by chronic peripheral infusion via osmotic minipumps, on a scopolamine-induced deficit in a Stone (14 unit) T-maze task in rats. Scopolamine alone (0.125-1.0 mg/kg, IP) dose-dependently

The effects of scopolamine on sleep and mood in depressed patients with a history of alcoholism and a normal comparison group.

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Ingia / Ingia

In order to determine the effect of an anticholinergic agent on mood and sleep, scopolamine (0.4 mg IM) was administered before bedtime for three consecutive nights to 10 depressed patients (8 with a history of alcohol abuse) and 10 normal comparison subjects. The patients had a small, statistically

REM sleep and cortisol responses to scopolamine during depression and remission in women.

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Ingia / Ingia

Baseline electroencephalographic (EEG) sleep and the EEG sleep response to scopolamine were studied in 10 adult female patients with unipolar major depressive disorder. Subjects were studied twice for two consecutive nights while depressed and, again, during remission. On the second night of each

Effects of repeated treatment with methamphetamine plus scopolamine and methamphetamine on behavioral sensitization and conditioning.

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Ingia / Ingia

This study compared repeated treatment with methamphetamine (4.0 mg/kg, i.p.) plus scopolamine (0.5 mg/kg, i.p.) and methamphetamine alone in behavioral sensitization and drug conditioning with respect to a reciprocal balance between the dopaminergic and cholinergic systems. Repeated methamphetamine

Comparison of behavioural effects of repeated treatment with methamphetamine plus scopolamine and methamphetamine alone on behavioural sensitization and conditioned response.

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Ingia / Ingia

We investigated how repeated treatments with methamphetamine (4.0 mg kg-1, i.p.) plus scopolamine (0.5 mg kg-1, i.p.) and methamphetamine alone effected behavioural sensitization and conditioned response in rats. Repeated methamphetamine plus scopolamine treatment induced a more progressive and

Effects of repeated doses of scopolamine on the electroencephalographic stages of sleep in normal volunteers.

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Ingia / Ingia

Single doses of scopolamine markedly alter sleep patterns in man. This study intended to evaluate the persistence of these changes during continued administration. The design consisted of a sequence of habituation, no-medication, saline (control), scopolamine (0.006 mg/kg intramuscularly 3

Comparative effects of scopolamine and quinpirole on the striatal fos expression induced by stimulation of D(1) dopamine receptors in the rat.

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Ingia / Ingia

Treatment of intact rats with the full D(1) dopamine agonist A-77636 induced Fos-like immunoreactivity in the medial and, to a lesser extent, the lateral portions of the striatum. Pretreatment with the muscarinic antagonist scopolamine hydrobromide (1.5-6 mg/kg) potentiated the response to A-77636

Intranasal scopolamine affects the semicircular canals centrally and peripherally.

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Ingia / Ingia

Space motion sickness (SMS), a condition caused by an intravestibular conflict, remains an important obstacle that astronauts encounter during the first days in space. Promethazine is currently the standard treatment of SMS, but scopolamine is used by some astronauts to prevent SMS. However, the

n-3 phosphatidylserine attenuated scopolamine-induced amnesia in middle-aged rats.

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Ingia / Ingia

Phosphatidylserine (PS) extracted from bovine brain differs from transphosphatidylated soybean lecithin PS (SB-PS) in its n-3 long-chain polyunsaturated fatty acid (LC-PUFA) content. Both, however, were suggested to affect cognitive performance. We compared the effect of chronic administration of a

Scopolamine and amphetamine produce similar decision-making deficits on a rat gambling task via independent pathways.

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Ingia / Ingia

Disorders characterized by disturbed cholinergic signaling, such as schizophrenia, exhibit impaired performance on measures of real-world cost/benefit decision-making. Whether the cholinergic system contributes to the choice deficits observed is currently unknown. We therefore determined the effects

Localization And Organization Of Scopolamine Biosynthesis In Duboisia myoporoides R. Br.

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Ingia / Ingia

Tropane alkaloids (TAs), especially hyoscyamine and scopolamine, are important precursors for anticholinergic and antispasmodic drugs. Hyoscyamine and scopolamine are currently obtained at commercial scale from hybrid crosses of Duboisia myoporoides × Duboisia leichhardtii plants. In this study, we

Influence of cholinesterase inhibitors on cortical slow-wave activity in aging nonhuman primate.

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Ingia / Ingia

Substantial evidence has now accumulated suggesting that the cognitive decrements characteristic of Alzheimer's disease and, to a lesser degree, of normal aging, may result, at least in part, from degenerative changes in the cholinergic system innervating archi- and neocortices. This evidence for

Acute effect of drugs upon memory of patients with senile dementia.

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Ingia / Ingia

Memory has been tested in senile demented patients with the Rey Auditory Verbal Learning Test. The processus of memorization can be significantly facilitated in acute conditions by lysin-vasopressin, to a lesser degree by piracetam and highly worsened by scopolamine. No effect of physostigmine has

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