lysolecithin/saratani

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Murine ascites tumour cells and lymphocytes. Effect of lysolecithin, organic mercurials and an anti-tumoral agent on the cell membrane permeability.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

An electron-microscope study of the effects of lysolecithin on BP8 ascites-tumour cells and phagocytes of mice, compared with the effects of a specific anti-tumour serum plus complement.

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Ingia / Ingia

Papaverine-induced changes in physiological characters of Ehrlich ascites tumor cell membranes.

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Ingia / Ingia

Physiological characters of Ehrlich ascites tumor cell membranes were altered by papaverine. The agent induced changes in membrane potential as monitored by cyanine dye (diS-C3-(5)) technique. Papaverine also strongly inhibited increase in membrane permeability to K+ ion induced by lysolecithin. In

Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome.

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Ingia / Ingia

Previous data have demonstrated that doxorubicin (DOX) released from a lysolecithin-containing thermosensitive liposome (LTSL) can shut down blood flow in a human tumor xenograft (FaDu) in mice when the treatment is combined with hyperthermia (HT), suggesting that LTSL-DOX is a potential

Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours.

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Ingia / Ingia

OBJECTIVE In previous reports, laboratory-made lysolecithin-containing thermosensitive liposome encapsulating doxorubicin (LTSL-DOX) showed potent anticancer effects in FaDu human squamous cell carcinoma. To further study the spectrum of LTSL-DOX activity, the efficacy of its commercial formulation

Correlation of increased acetate binding with alkylating agent resistance in Walker and Yoshida tumor cells.

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Ingia / Ingia

The utilization of acetate is fundamental to numerous cellular processes. At the level of chromatin, histone acetylation is thought to regulate transcription, and acetate is a major source of cellular energy as it is the substrate for the citric acid cycle. The present work investigates the

Shikimic Acid Promotes Oligodendrocyte Precursor Cell Differentiation and Accelerates Remyelination in Mice.

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Ingia / Ingia

The obstacle to successful remyelination in demyelinating diseases, such as multiple sclerosis, mainly lies in the inability of oligodendrocyte precursor cells (OPCs) to differentiate, since OPCs and oligodendrocyte-lineage cells that are unable to fully differentiate are found in the areas of

Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis.

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Ingia / Ingia

Proteoglycans are promising therapeutic targets in Multiple Sclerosis (MS), because they regulate many aspects of the immune response. This was studied using surfen, an agent that binds both heparan sulphate proteoglycans (HSPGs) and chondroitin sulphate proteoglycans (CSPGs). Initial cell culture

Campesin, a thermostable antifungal peptide with highly potent antipathogenic activities.

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Ingia / Ingia

An 9.4-kDa antifungal peptide designated as campesin was isolated from seeds of the cabbage Brassica campestris. The isolation procedure involved affinity chromatography on Affi-gel blue gel, ion exchange chromatography on Q-Sepharose and Mono S, and gel filtration on Superdex 75 and Superdex

Hexadecylphosphocholine: a new and selective antitumor drug.

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Ingia / Ingia

Interdisciplinary cooperation between basic and clinical research has resulted in the discovery and development of alkylphosphocholines, a new class of substances for the treatment of breast cancer. In contrast to most antitumor substances, the alkylphosphocholines do not attack the cell nucleus,

Levodopa and dopamine analogs as DNA polymerase inhibitors and antitumor agents in human melanoma.

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Ingia / Ingia

Levodopa and dopamine are naturally occurring catecholamines with antitumor activity in several experimental tumor systems. Previous studies suggested that their cytotoxic effect was related in part to their inhibitory effect upon DNA polymerase. We have examined the effects of levodopa, dopamine,

On the molecular structure of some prostaglandin receptors.

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Ingia / Ingia

Hypotheses are presented of the detailed molecular structure of two prostaglandin receptors both concerned in tumor-promotion processes. These structures have been derived by the comparison of the molecular structure of agents active at the site with (i) a simple theoretical protein structure and

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