necine/carcinogenesis

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NakalaMajaribio ya klinikiHati miliki

Chagua aina ya aina

2 matokeo

Metabolic activation of retronecine and retronecine N-oxide - formation of DHP-derived DNA adducts.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

We have previously reported that metabolism of a series of pyrrolizidine alkaloids in vitro and in vivo generated a set of (+/-)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts. It has also been shown that the levels of the DHP-derived DNA adduct formation correlated

Full structure assignments of pyrrolizidine alkaloid DNA adducts and mechanism of tumor initiation.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Pyrrolizidine alkaloid-containing plants are widespread in the world and are probably the most common poisonous plants affecting livestock, wildlife, and humans. Pyrrolizidine alkaloids are among the first chemical carcinogens identified in plants. Previously, we determined that metabolism of

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Herbal & Natural Medicine

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