PCOS patients receiving abstract of cinnamon

Purified aqueous abstract of cinnamon in 125mg capsules
Cinnamon Extract: Purified aqueous abstract of cinnamon in 125mg capsules, which would be taken orally before each meal, for a total of 1,500mg/day for 6 months.

Cinnamon Extract Arm

Placebo capsules containing ground cereal.
Placebo: Placebo capsules containing ground cereal.

Placebo Arm

Total

Sex: Female, Male

Ethnicity (NIH/OMB)

Region of Enrollment

Ovulatory cycles will be confirmed by serum progesterone levels.

Purified aqueous abstract of cinnamon in 125mg capsules
Cinnamon Extract: Purified aqueous abstract of cinnamon in 125mg capsules, which would be taken orally before each meal, for a total of 1,500mg/day for 6 months.
Baseline (no. of cycles/month) 0.42 Study period (no. of cycles/month) 0.75 Change during study +/- cycles/month +0.23

Placebo capsules containing ground cereal.
Placebo: Placebo capsules containing ground cereal.
Baseline (no. of cycles/month) 0.42 Study period (no. of cycles/month) 0.25 Change during study +/- cycles/month -0.13

Number of Menses During the Six Month Study Period.

The changes in insulin resistance parameters in overweight patients with PCOS between baseline and after 6 months of daily cinnamon compared to the corresponding change in patients receiving 6 months of placebo. Higher values of insulin resistance represent a worse outcome. A higher value Homeostasis Model of Insulin Resistance indicates more insulin resistance so higher values are worse outcomes (a score of >2 is considered healthy for adults with scores >5 being considered severe insulin resistance). For the Quant. Insulin Sensitivity Check Index, a lower value indicates more insulin resistance so lower values are worse outcomes (values can range from .45, which is considered normal in health individuals and .30, which is characteristic of diabetes).

Change in Insulin Resistance

Change in Glucose Response - area under the curve (AUC), trapezoidal method - in overweight patients with PCOS between baseline and after 6 months of daily cinnamon compared to the corresponding change in patient receiving 6 months of placebo. Fasting blood samples were drawn followed by a 2 hour glucose tolerance test with blood draws at 30, 60, and 120min post glucose ingestion.

Change in Glucose Response

Overall Study

Roger A. Lobo M.D.

PCOS patients receiving extract of cinnamon
Cinnamon Extract: Purified aqueous abstract of cinnamon in 125mg capsules, which would be taken orally before each meal, for a total of 1,500mg/day for 6 months.

PCOS patients receiving placebo capsules
Placebo: Placebo capsules containing ground cereal.

Polycystic Ovary Syndrome

Purified aqueous abstract of cinnamon in 125mg capsules, which would be taken orally before each meal, for a total of 1,500mg/day for 6 months.

Cinnamon Extract

Placebo capsules containing ground cereal.

oligomenorrhea/cinnamon

Cinnamon Extract on Menstrual Cycles in PolyCystic Ovary Syndrome (PCOS)

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