paris vietnamensis/glioblastoma

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NakalaMajaribio ya klinikiHati miliki

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2 matokeo

A steroidal saponin form Paris vietnamensis (Takht.) reverses temozolomide resistance in glioblastoma cells via inducing apoptosis through ROS/PI3K/Akt pathway.

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Ingia / Ingia

Glioblastoma is one of the most difficult cancers to treat with a 5-year overall survival rate less than 5%. Temozolomide (TMZ) is an effective drug for prolonging the overall survival time of patients, while drug-resistance is an important clinical problem at present.

New Steroidal Saponins from the Rhizomes of Paris vietnamensis and Their Cytotoxicity.

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Ingia / Ingia

Four new spirostanol saponins, named pavitnosides A-D (1-4), with six known steroidal saponins 5-10 were isolated from the rhizomes of Paris vietnamensis. Their chemical structures were determined based on extensive spectroscopic studies and chemical methods. The aglycones of pavitnoside B and

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Herbal & Natural Medicine

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