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pneumococcal infections/carbohydrate

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[Study on carbohydrate and insulin metabolism in experimental pneumococcal infections].

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
Total hepatic water content, dry weight, protein, lipid, carbohydrate, RNA, DNA, and electrolyte concentrations were determined in control and Streptococcus pneumoniae-infected rats. During infection, there was a significant (P = 0.001) increase in total liver weight. This increase was the result of
The complement (C) profile was investigated in an adult patient with combined IgG2, IgG4 and IgA deficiency and recurrent pneumococcal infections. The analysis revealed no gross impairment of the classic and alternative pathways of C activation. However, the concentrations of circulating C1q were
SIGN-R1, or CD209b, is a mouse C-type lectin receptor that is expressed at high levels on macrophages in lymphoid tissues, especially within the marginal zone of the spleen. SIGN-R1 can bind and mediate the uptake of various microbial polysaccharides, including dextrans, lipopolysaccharides and

[A method for preventing experimental pneumococcal infection].

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
Lethal pneumococcal infection in mice, infected intranasally, can be induced only by highly virulent strains of pneumococci. The introduction of N-acetylglucosamine and/or D-galactose, both 1 hour before the introduction of pneumococci or simultaneously with their introduction, prevented the
In the present study, we have characterized the dihydrolipoamide dehydrogenase (DLDH) of Strepto-coccus pneumoniae and its role during pneumococcal infection. We have also demonstrated that a lack of DLDH results in a deficiency in alpha-galactoside metabolism and galactose transport. DLDH is an

Capacity To Utilize Raffinose Dictates Pneumococcal Disease Phenotype.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
Streptococcus pneumoniae is commonly carried asymptomatically in the human nasopharynx, but it also causes serious and invasive diseases such as pneumonia, bacteremia, and meningitis, as well as less serious but highly prevalent infections such as otitis media. We have previously shown that

Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
L-ficolin is a pattern-recognition molecule which binds lipoteichoic acid and Gram-positive bacteria and activates the lectin pathway of complement. Five common functional polymorphisms have recently been identified in the FCN2 gene which encodes L-ficolin: three promoter polymorphisms (at positions

C-reactive protein is protective against Streptococcus pneumoniae infection in mice.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
C-reactive protein (CRP) has several properties that suggest that it may function as a bacterial opsonin. CRP shows binding reactivity with pneumococcal C-polysaccharide, the cell wall carbohydrate of Streptococcus pneumoniae. In this study we have demonstrated protection of mice against serotypes 3

A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
Severe forms of pneumococcal meningitis, bacteraemia and pneumonia result in more than 1 million deaths each year despite the widespread introduction of carbohydrate-protein conjugate vaccines against Streptococcus pneumoniae. Here we describe a new and highly efficient antipneumococcal vaccine
Aim: The article presents data on the evaluation of the clinical efficacy of using a conjugated pneumococcal vaccine in patients with COPD in combination with 2-type diabetes during a 3-year follow - up period.

Protein-sparing therapy during pneumococcal infection in rhesus monkeys.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
A model was developed in the rhesus monkey to determine if the marked wasting of body proteins associated with sepsis could be prevented by an intravenous supply of various nutritional substrates. All monkeys were given a basic infusion of 0.5 gm of amino acid nitrogen/kg body weight via an

Effects of training on metabolic responses and performance capacity in Streptococcus pneumoniae infected rats.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
These experiments were designed to study whether endurance training prior to Streptococcus pneumoniae infection in rats (N = 15 in each group) alters lethality, performance capacity, and related energy metabolism. A 5-d.wk-1, 4-wk-long pre-infection training program with gradually increasing swim

Epidemiological studies of Streptococcus pneumoniae in infants: development of antibody to phosphocholine.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala
Ingia / Ingia
The pneumococci possess, in addition to type-specific capsular polysaccharides, a number of antigens common to the species. Antibodies to phosphocholine (PC), a major determinant of the C-carbohydrate, have been shown to protect mice from experimental pneumococcal infection, but little is known of
We have compared the abilities of IgG1, IgG2b, and IgG3 antibodies to protect mice against infection with a bacterial pathogen for which antibody-mediated protection is thought to be a function of killing by phagocytes rather than complement-mediated lysis. For this study, we used
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