quillaic acid/saponaria

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Antiproliferative quillaic acid and gypsogenin saponins from Saponaria officinalis L. roots.

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Ingia / Ingia

Nine quillaic acid and five gypsogenin bisdesmosides were isolated from roots of Saponaria officinalis L. (Caryophyllaceae). Seven of the quillaic acid saponins possessed a 3-O-β-D-galactopyranosyl-(1 → 2)-[β-D-xylopyranosyl-(1 → 3)]-β-D-glucuronopyranosyl unit, but differed from each other in

Analysis of bisdesmosidic saponins in Saponaria vaccaria L. by HPLC-PAD-MS: identification of new quillaic acid and gypsogenin 3-O-trisaccharides.

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Ingia / Ingia

A high-performance liquid chromatographic method using photodiode array and single quadrupole electrospray mass detection for analysis and profiling of bisdesmosidic saponins in Saponaria vaccaria seed was developed. Profiles of seed extract from three different plant sources were obtained and found

Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice.

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Ingia / Ingia

BACKGROUND Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine. OBJECTIVE The topical and systemic analgesic effects of a commercial partially purified saponin extract,

Antihyperalgesic Activity of Quillaic Acid Obtained from Quillaja Saponaria Mol.

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Ingia / Ingia

Quillaja saponaria Mol. bark contains a high concentration of triterpene saponins that have been used for centuries as a cleansing, antiinflammatory and analgesic agent in Chilean folk medicine. In earlier studies, in mice, both the anti-inflammatory as well as the antinociceptive

Topical anti-inflammatory activity of quillaic acid from Quillaja saponaria Mol. and some derivatives.

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Ingia / Ingia

OBJECTIVE Quillaic acid is the major aglycone of the widely studied saponins of the Chilean indigenous tree Quillaja saponaria Mol. The industrial availability of quillaja saponins and the extensive functionalization of this triterpenoid provide unique opportunities for structural modification and

In vitro evaluation and molecular docking of QS-21 and quillaic acid from Quillaja saponaria Molina as gastric cancer agents

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Ingia / Ingia

The cytotoxic mechanism of the saponin QS-21 and its aglycone quillaic acid (QA) was studied on human gastric cancer cells (SNU1 and KATO III). Both compounds showed in vitro cytotoxic activity with IC₅₀ values: 7.1 μM (QS-21) and 13.6 μM (QA) on SNU1 cells; 7.4 μM (QS-21) and 67 μM (QA)

Structure-activity relationships of saponins enhancing the cytotoxicity of ribosome-inactivating proteins type I (RIP-I).

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Ingia / Ingia

Saponins are amphiphilic secondary plant compounds able to interfere with surfaces and permeabilize membranes. In addition to antimicrobial and anti-inflammatory features, anti-neoplastic activities are described which base on various mechanisms. A very promising anti-cancer strategy is the

Major triterpenoid saponins from saponaria officinalis

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Ingia / Ingia

Two major triterpenoid saponins, named saponariosides A and B, were isolated from the whole plants of Saponaria officinalis and were respectively defined to be 3-O-beta-D-galactopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->3)]-be ta-D-glucuronopyranosyl quillaic acid

Saponaria officinalis L. extract: Surface active properties and impact on environmental bacterial strains.

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Ingia / Ingia

Plant-derived surfactants are characterised by low toxicity, high biodegradability and environmental compatibility. They therefore have many applications; for instance, they can be used in bioremediation to accelerate biodegradation processes, especially of hydrophobic pollutants. This paper

Triterpenoid saponins from Quillaja saponaria.

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Ingia / Ingia

Three new saponins were isolated from a commercial bark extract of Quillaja saponaria Molina. These compounds were also obtained as degradation products from larger saponins in this extract when treated with strong alkali. The compounds were characterized, using mainly NMR spectroscopy, mass

Novel acetylated triterpenoid saponins in a chromatographic fraction from Quillaja saponaria Molina.

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Ingia / Ingia

Six novel fucose 3-O-acetylated saponins, with a quillaic acid aglycone, were isolated from a bark extract from the Quillaja saponaria Molina tree. In addition, a saponin with a novel aglycone (phytolaccagenic acid) and a novel fatty acyl group [(S)-2-methylbutanoyl] for Quillaja saponins was found.

Characterization of some O-acetylated saponins from Quillaja saponaria Molina.

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Ingia / Ingia

Sixteen saponins were identified from a bark extract of Quillaja saponaria Molina. The compounds were characterized, using NMR spectroscopy, mass spectrometry and monosaccharide analysis, as quillaic acid substituted at C-3 with oligosaccharides consisting of a disaccharide,

Triterpenoid saponins containing an acetylated branched D-fucosyl residue from Quillaja saponaria Molina.

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Ingia / Ingia

Seven novel saponins were isolated from a bark extract of Quillaja saponaria Molina. the compounds were characterized, using mainly NMR spectroscopy, mass spectrometry and chemical methods, as quillaic acid substituted at C-3 with oligosaccharides consisting of various compositions of D-glucuronic

Structural studies of triterpenoid saponins with new acyl components from Quillaja saponaria Molina.

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Ingia / Ingia

Eight new triterpenoid saponins were isolated from a bark extract of Quillaja saponaria Molina by silica and reverse phase chromatography. The saponins were characterized by spectroscopic data and chemical methods as phytolaccagenic acid, 22beta-hydroxy-quillaic acid, and echinocystic acid

Separation and structural analysis of some saponins from Quillaja saponaria Molina.

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Ingia / Ingia

A fraction of saponins from Quillaja saponaria Molina, QH-B, was fractionated by consecutive separations on three different reverse-phase HPLC systems. Eight compounds were isolated and the structures of these were elucidated mainly by sugar analysis and NMR spectroscopy. The structures consisted of

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