rhodojaponin/rhododendron molle

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Induction of intracellular Ca2+ and pH changes in Sf9 insect cells by rhodojaponin-III, a natural botanic insecticide isolated from Rhododendron molle.

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Ingia / Ingia

Many studies on intracellular calcium ([Ca2+](i)) and intracellular pH (pH(i)) have been carried out due to their importance in regulation of different cellular functions. However, most of the previous studies are focused on human or mammalian cells. The purpose of the present study was to

Laboratory and field evaluations of rhodojaponin-III against the imported cabbage worm Pieris rapae (L.) (Lepidoptera: Pieridae).

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Ingia / Ingia

The activity of rhodojaponin-III (R-III), a grayanoid diterpene compound isolated from Rhododendron molle G. Don flowers, was determined under laboratory and field conditions as an antifeedant, stomach poison, contact toxicant and insect growth inhibitor against Pieris rapae (L.) larvae. The median

[Studies on the chemical constituents of Rhododendron molle G. Don].

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Ingia / Ingia

Two physiologically active diterpenoids were isolated from the flower of Chinese azalea (Ericaceae Rhododendron molle G. Don). One of them is a new compound, named rhodomollein-III; its structure has been established as 1 through IR, MS, 1HNMR, 13C NMR, 1H-1H COSY, 1H-1H NOESY, 13C-1H COSY and

Pharmacokinetics, bioavailability and tissue distribution studies of rhodojaponin III in mice using QTRAP LC-MS/MS.

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Ingia / Ingia

Rhodojaponin III is a bioactive diterpenoid isolated from the medicinal plant Rhododendron molle G. Don. Quantitative analysis of rhodojaponin III was challenging and the pharmacokinetics of oral rhodojaponin III remained to be investigated. Here, a rapid and sensitive liquid chromatography tandem

Molecular cloning, expression and molecular modeling of chemosensory protein from Spodoptera litura and its binding properties with Rhodojaponin III.

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Ingia / Ingia

Insects stimulate specific behaviors by the correct recognition of the chemicals in the external environment. Rhodojaponin III is a botanical grayanoid diterpenid oviposition deterrent isolated from Rhododendron molle. In this study we aimed to determine whether the CSPs involved in the recognition

Rhodojaponin II attenuates kidney injury by regulating TGF-β1/Smad pathway in mice with adriamycin nephropathy.

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Ingia / Ingia

Rhododendron molle G. Don (Ericaceae) (RM) is a natural medicinal plant. Its root extracts have been applied in clinic and proved to be effective in chronic glomerulonephritis and rheumatoid arthritis in China. Surprising, little is understood about the key compound of RM and the exact

Studies on the chemical constituents of the roots of Rhododendron molle G. Don.

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Ingia / Ingia

The compounds from the root of Rhododendron molle G. Don were isolated, purified by various chromatographic techniques, and their structures were identified according to the physical and chemical features and spectral data. Three compounds were separated from the root of Rhododendron molle G. Don

Diterpenoids from the fruits of Rhododendron molle.

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Ingia / Ingia

Four new diterpenoids, rhodomolleins XV (1), XVI (2), XVII (3), and XVIII (4), together with three known diterpenoids, kalmanol and rhodojaponins III and VI, were isolated from the dried ripe fruits of Rhododendron molle. Their structures were elucidated on the basis of spectroscopic data

Diterpenoids from the flowers of Rhododendron molle.

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Ingia / Ingia

Five new grayanane-type diterpenoids, rhodomolleins IX (1), X (2), XI (3), XII (4), and XIII (5), a new kalmane-type diterpenoid, rhodomollein XIV (6), and seven known diterpenoids, grayanotoxin II, rhodomolleins I and XIX, rhodojaponins II, III, and VI (7), and kalmanol, were isolated from the

Grayanane diterpenoids from the flowers of Rhododendron molle with cytotoxic activity against a Spodoptera frugiperda cell line.

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Ingia / Ingia

Two new grayanane diterpenoids, rhodomolins A (1) and B (2), together with two known diterpenoids, rhodomolleins I and rhodojaponin III, were isolated from the flowers of Rhododendron molle. The structures of 1 and 2 were elucidated on the basis of interpretation of spectroscopic data. All compounds

Mollebenzylanols A and B, Highly Modified and Functionalized Diterpenoids with a 9-Benzyl-8,10-dioxatricyclo[5.2.1.01,5]decane Core from Rhododendron molle.

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Ingia / Ingia

Two highly modified and functionalized diterpenoids, mollebenzylanols A (1) and B (2), and a known grayanane diterpenoid rhodojaponin III (3) were isolated from Rhododendron molle. Their structures were determined by spectroscopic data analysis, an electronic circular dichroism (ECD) exciton

Tandem solid-phase extraction followed by HPLC-ESI/QTOF/MS/MS for rapid screening and structural identification of trace diterpenoids in flowers of Rhododendron molle.

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Ingia / Ingia

BACKGROUND 'Naoyanghua', composed of the flowers of Rhododendron molle G. Don, is a traditional Chinese medicine that is widely known for its toxicity. Grayanane-type diterpenoids are the main active ingredients in R. molle, as well as possibly their toxicity: they are, however, difficult to isolate

Rhododendron Molle (Ericaceae): phytochemistry, pharmacology, and toxicology.

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Ingia / Ingia

Rhododendron molle G. Don, belonging to the Ericaceae family, is a traditional Chinese medicinal plant with a wide spectrum of pharmacological effects. This paper aimed to review the phytochemistry, pharmacology and toxicology of R. molle, and to discuss the tendency of future investigations on this

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