sialadenitis/protease

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NakalaMajaribio ya klinikiHati miliki

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5 matokeo

Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse.

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Ingia / Ingia

We developed a panel of non-obese diabetic (NOD) mice deficient in major lysosomal cysteine proteases (cathepsins S, L and B) to identify protease enzymes essential for autoimmune diabetes. Null alleles for cathepsins (Cts) S, L or B were introgressed onto the NOD genetic background with 19 Idd

Salivary gland changes in the NOD mouse model for Sjögren's syndrome: is there a non-immune genetic trigger?

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Ingia / Ingia

Sjögren's syndrome is a systemic autoimmune disease characterized by patient complaints of oral and ocular dryness accompanied by clinical observations of a progressive loss of salivary and lacrimal function, related to the presence of a focal, periductal leukocyte infiltrate. Progress in

Expression of secretory leukocyte proteinase inhibitor in the submandibular glands of AIDS patients.

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Ingia / Ingia

OBJECTIVE Secretory leukocyte proteinase inhibitor (SLPI) is an endogenous proteinase inhibitor present in mucosal secretions. It also displays antimicrobial activity including anti-human immunodeficiency virus activity. This protease inhibitor is also expressed in submandibular glands (SMG), but

Altered fractalkine cleavage potentially promotes local inflammation in NOD salivary gland.

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Ingia / Ingia

BACKGROUND In the nonobese diabetic (NOD) mouse model of Sjögren's syndrome, lymphocytic infiltration is preceded by an accumulation of dendritic cells in the submandibular glands (SMGs). NOD mice also exhibit an increased frequency of mature, fractalkine receptor (CX3C chemokine receptor [CX3CR]1)

Apoptosis and Sjögren syndrome.

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Ingia / Ingia

OBJECTIVE To examine the role of apoptosis in the pathogenesis of Sjögren syndrome (SS), a chronic autoimmune disease characterized by the infiltration of mononuclear cells in the salivary and lacrimal glands, leading to the destruction of the parenchymal tissue. METHODS A detailed search via

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Herbal & Natural Medicine

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