Ampicillin arm: Patients will receive four doses of parenteral Ampicillin and single dose of Gentamicin daily for 3-5 days

Amoxicillin arm: Patients will receive two doses of Amoxicillin and single dose of Gentamicin daily for 3-5 days

Treatment Failure

Lethargy

Altered Mental Status

Convulsion, Non-Epileptic

Hypoxia

Feeding; Difficult, Newborn

Twice daily doses of injectable amoxicillin

Amoxicillin

Dhaka Hospital, icddr,b

RCT of Efficacy of Amoxicillin Over Ampicillin on Severe Pneumonia

Efficacy of Two Doses of Parenteral Amoxicillin Plus Single Dose Gentamicin Compared to Four Doses of Parenteral Ampicillin Plus Single Dose Gentamicin in Managing Children Hospitalized With WHO Classified Severe Pneumonia: a RCT

Persistence of danger signs of severe pneumonia such as hypoxia, feeding difficulty, abnormal mentation after 48 hours or new appearance of danger sign within 24 hours

Recovery from features of pneumonia in terms of respiratory distress, abnormal chest auscultation finding

any hospital acquired infection proven by laboratory facility

Follow up over phone to get information of any mild illness at home after discharge

International Centre for Diarrhoeal Disease Research, Bangladesh

Use of the HFCC device in addition to standard therapy for status asthmaticus. The use of HFCC will not affect the therapy received

This group will not use the VEST or HFCC. They will just have standard therapy for status asthmaticus. The standard therapy will not be affected if they are in this group.

Use of the HFCC device in addition to standard therapy for status asthmaticus. The use of HFCC will not affect the therapy received
High Frequency Chest Compression VEST: every 6 hours for 20 minutes

Pediatric Status Asthmatics Patients on HFCC Device

Pediatric Status Asthmaticus Patients Not Using HFCC

Total

Sex: Female, Male

Race/Ethnicity, Customized

Region of Enrollment

Prior Hospitalizations

Please note that because one subject may be on multiple classes of medication so the numbers will not add up

Home asthma medication

Modified Pulmonary Index Score (MPIS): a validated asthma severity score in pediatric population (Carroll CL et al. A modified pulmonary index score with predictive value for pediatric asthma exacerbations, Ann Allergy Asthma Immunol 2005) Consists of: 1) oxygen saturation on room air 2) accessory muscle use 3) inspiratory to expiratory ratio 4) degree of wheezing 5) heart rate 6) respiratory rate. Scored observations 0, 1, 2 or 3. Total score range 0-18.
Mild exacerbation total less than 6, moderate exacerbation 6 - 10, severe exacerbation higher than 10

Modified Pulmonary Index Score (Initial)

Hours Spent in Pediatric ICU

This is limited due to non collection by collaborating centers.

Total Days of Hospital Admission

Modified Pulmonary Index Score (MPIS): a validated asthma severity score in pediatric population (Carroll CL et al. A modified pulmonary index score with predictive value for pediatric asthma exacerbations, Ann Allergy Asthma Immunol 2005) Consists of: 1) oxygen saturation on room air 2) accessory muscle use 3) inspiratory to expiratory ratio 4) degree of wheezing 5) heart rate 6) respiratory rate Scored observations 0, 1, 2 or 3. Total score range 0 - 18. Mild exacerbation total less than 6, moderate exacerbation 6 - 10, severe exacerbation higher than 10

status asthmaticus/hypoxia

RCT of Efficacy of Amoxicillin Over Ampicillin on Severe Pneumonia

Use of High Frequency Chest Compression in Pediatric Status Asthmaticus

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