tabernanthine/hypoxia

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Evidence for an antagonistic action of tabernanthine on hypoxia-induced changes in brain serotonin levels.

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The effects of tabernanthine on serotonin (5-HT) levels were determined in several brain areas of rats exposed to various simulated altitudes (1800, 5200, 7000 m). The 5-HT synthesis inhibitor, para-chlorophenylalanine (PCPA), was used to dissociate the effects occurring at synthesis and release

Effect of tabernanthine on the turnover time of brain catecholamines in normal and hypobaric hypoxic rats.

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Ingia / Ingia

The central effects of tabernanthine on noradrenaline and dopamine turnover times were studied in the hypothalamus, the striatum and the remainder of the brain of normal and hypobaric hypoxic rats, the latter state corresponding to 5,200m (410mm Hg) and 7,000m (320mm Hg). Catecholamine cerebral

Evidence for an activating effect of tabernanthine on rat brain catecholamine synthesis and elimination.

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Ingia / Ingia

Tabernanthine increased the synthesis and elimination of catecholamines (CA) in the striatum and the rest of the brain, but not in the hypothalamus. These data provide evidence that tabernanthine may activate CA turnover of some brain structures by acting at 2 steps of the metabolic pathway. The

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Herbal & Natural Medicine

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