5 matokeo
OBJECTIVE
To investigate the molecular mechanisms of tauopathies. Comparative proteomic analysis of brain proteins was employed to study 4 patients with tauopathies as compared with 4 controls.
METHODS
The brains of subjects who died without clinical or pathological involvement of nervous system and
OBJECTIVE
To identify differentially expressed proteins between tauopathies cases and controls and to explore molecular mechanisms of tauopathies.
METHODS
Two-dimensional gel electrophoresis (2DE) was applied to separate the total proteins of temporal lobe obtained at autopsy from four tauopathies
The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic encephalopathy, and the relationships between these disorders, are poorly understood. We examined post-mortem brains from teenage athletes in the acute-subacute period after mild closed-head impact injury and found
Repetitive mild traumatic brain injury in American football players has garnered increasing public attention following reports of chronic traumatic encephalopathy, a progressive tauopathy. While the mechanisms underlying repetitive mild traumatic brain injury-induced neurodegeneration are unknown
Alzheimer's disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (Aβ) protein and intracellular aggregates of tau protein. Although tau is normally a soluble monomer that bind microtubules, in disease it forms insoluble,