thapsia silphia/histamine

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Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [14C]arachidonic acid and histamine from rat peritoneal mast cells.

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Ingia / Ingia

Thapsigargin is a potent skin irritating sesquiterpene lactone isolated from the roots of Thapsia garganica L. (Apiaceae). In rat peritoneal mast cells thapsigargin induced a calcium-dependent non-cytotoxic [14C]arachidonic acid and histamine release. A minor amount of the released [14C]arachidonic

On the mechanism of histamine release induced by thapsigargin from Thapsia garganica L.

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Ingia / Ingia

Thapsigargin (Tg) is a pure chemical compound isolated from Thapsia garganica with a molecular weight of 650. It releases histamine from isolated rat mast cells but not from isolated histamine-retaining mast cell granules. The rate of release is markedly influenced by pretreatment of mast cells with

Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica L.

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Ingia / Ingia

Phytochemistry of the genus Thapsia.

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Ingia / Ingia

In a chemotaxonomic study of the genus Thapsia (Apiaceae), root material of five taxa has been analysed for skin irritating sesquiterpene lactones and the coumarins, 6-methoxy-7-geranyloxycoumarin and scopoletin. Eight tetraesters of 2, 3, 7, 8, 10, 11-hexahydroxy-C (6)-guaianolide and two triesters

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Herbal & Natural Medicine

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