timosaponin b/anemarrhena asphodeloides

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Antiplatelet and antithrombotic activities of timosaponin B-II, an extract of Anemarrhena asphodeloides.

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Ingia / Ingia

1. Antithrombotic agents are effective in the treatment of ischaemic stroke. Timosaponin B-II (TB-II) is a major active component of Anemarrhena asphodeloides Bunge (Liliaceae; rhizome) that has protective effects against cerebral ischaemic damage. The present study examined the antiplatelet and

[Effects of different processing methods on five main chemical constituents of Anemarrhena asphodeloides Bge. studied by high performance liquid chromatography].

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Ingia / Ingia

A high performance liquid chromatographic (HPLC) method has been developed for the simultaneous determination of neomangiferin, mangiferin, timosaponin B III, anemarrhenasaponin I and timosaponin A III in the products of Anemarrhena asphodeloides Bge. processed by different methods. By comparing and

New steroidal saponins from the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae).

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Ingia / Ingia

From the rhizome of Anemarrhena asphodeloides Bunge (Liliaceae), four new steroidal saponins named anemarrhenasaponins I-IV (1-4) were isolated, together with known saponins, timosaponin A-III (5), marcogenin diglycoside (6) and timosaponin B-II (7) and a xanthone C-glycoside, mangiferin. These

Steroidal saponins from Anemarrhena asphodeloides and their effects on superoxide generation.

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Ingia / Ingia

A new steroidal saponin, timosaponin F, along with six known compounds was isolated from the rhizomes of Anemarrhena asphodeloides Bge. On the basis of chemical and spectroscopic evidence, the structure of timosaponin F was elucidated as (5beta, 25 S):-spirostan-3beta,15alpha,23alpha-triol-3-O-beta-

Steroidal saponins from Anemarrhena asphodeloides.

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Ingia / Ingia

Two new steroidal saponins, named anemarnoside A and anemarnoside B, along with three known compounds, timosaponin J, timosaponin B II, and timosaponin B, have been isolated from Anemarrhena asphodeloides. Their structures were established by spectroscopic techniques (IR, MS, 1D NMR, and 2D NMR) and

Folding fan mode counter-current chromatography offers fast blind screening for drug discovery. Case study: finding anti-enterovirus 71 agents from Anemarrhena asphodeloides.

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Ingia / Ingia

A new application of counter-current chromatography (CCC) in drug discovery, called folding fan mode (FFM), is designed to eliminate the extensive and time-consuming calculation of the partition coefficients of some preset compounds in conventional CCC separation. Careful reading of reports in the

New transformation pathway and cytotoxic derivatives from the acid hydrolysis of timosaponin B III.

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Ingia / Ingia

Timosaponin B III is a major bioactive steroidal saponin isolated from Anemarrhena asphodeloides Bge. To potentially discover derivatives with better biological activity, timosaponin B III was structurally modified via acid hydrolysis to yield one new (2, timopregnane A I) C21 steroidal glycoside

Timosaponin B-II inhibits lipopolysaccharide-induced acute lung toxicity via TLR/NF-κB pathway.

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Ingia / Ingia

Timosaponin B-II (TB), a main bioactive compound in Anemarrhena asphodeloides Bunge, has various kinds of pharmacological activities, the present study aimed to investigate the protective role of TB on lipopolysaccharide (LPS)-induced acute lung injury (ALI). ALI was induced in mice by intratracheal

A novel LC-MS/MS method for determination of tissue distribution and excretion of timosaponin B-II in rat biological matrices.

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Ingia / Ingia

Timosaponin B-II (TB-II) is a natural bioactive steroid glycoside extracted from the Chinese medicinal herb Anemarrhena asphodeloides Bge. (Fam. Liliaceae). It has been demonstrated to have a good anti-inflammatory effect and a low bioavailability (1.1%). Clinical research has focused on developing

[Study on the extraction process and macroporous resin for purification of Timosaponin B II].

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Ingia / Ingia

OBJECTIVE To optimize the extraction process and macroporous resin for purification of Timosaponin B II from Anemarrhena asphodeloides. METHODS Orthogonal design L9 (34) was employed to optimize the circumfluence extraction conditions by taking the extraction yield of Timosaponin B II as index. The

A Timosaponin B-II containing scalp care solution for improvement of scalp hydration, dandruff reduction and hair loss prevention: A comparative study on healthy volunteers before and after application

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Ingia / Ingia

Background: The plant species Anemarrhena asphodeloides has commonly been used for health and therapeutic purposes. Timosaponin B-II, which is present at a high concentration in A. asphodeloides, was found to enhance the immune and

Metabolism profile of timosaponin B-II in urine after oral administration to rats by ultrahigh-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.

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Ingia / Ingia

BACKGROUND Timosaponin B-II (TB-II) is one of the major bioactive steroid glycosides isolated from Anemarrhena asphodeloides Bge. (Fam. Liliaceae). It has been regarded as a potential lead compound, which may be further developed into a promising new drug for preventing dementia. To fully understand

A rapid and sensitive liquid chromatography-tandem mass spectrometric method for the determination of timosaponin B-II in blood plasma and a study of the pharmacokinetics of saponin in the rat.

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Ingia / Ingia

A rapid, sensitive and selective liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the determination of Timosaponin B-II (TB-II), a pharmacologically active constituent isolated from Anemarrhena asphodeloides. This method was used to examine the

Timosaponin B-II ameliorates diabetic nephropathy via TXNIP, mTOR, and NF-κB signaling pathways in alloxan-induced mice.

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Ingia / Ingia

BACKGROUND Many synthesized drugs with clinical severe side effects have been used for diabetic nephropathy (DN) treatment. Therefore, it is urgent and necessary to identify natural and safe agents to remedy DN. Timosaponin B-II (TB-II), a major steroidal saponin constituent in Anemarrhena

Coordinate regulatory osteogenesis effects of icariin, timosaponin B II and ferulic acid from traditional Chinese medicine formulas on UMR-106 osteoblastic cells and osteoblasts in neonatal rat calvaria cultures.

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Ingia / Ingia

BACKGROUND Icariin (I), ferulic acid (F) and timosaponin B II (T) derived respectively from the leaf of Epimedium brevicornu Maxim (EBM, Berberidaceae), rhizome of Anemarrhena asphodeloides Bunge (AAB, Liliaceae) and root of Angelica sinensis (Oliv.) Diels (ASD, Umbelliferae) are included in several

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