uridine 5 monophosphate/colorectal neoplasms

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NakalaMajaribio ya klinikiHati miliki

Chagua aina ya aina

3 matokeo

Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2'-deoxy-uridine-5'-monophosphate.

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Ingia / Ingia

Inhibition of thymidylate synthase (TS) by the 5-fluorouracil (5-FU) metabolite FdUMP is considered to be the main mechanism of action of 5-FU. TS from colorectal tumours and normal colon mucosa from 10 untreated patients was studied. There was a large variation in the activity of tumour TS both at

A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa.

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Ingia / Ingia

The metabolism of 5-fluorouracil (5-FU) was studied in biopsy specimens of primary colorectal cancer and healthy colonic mucosa obtained from previously untreated patients immediately after surgical removal. The conversion of 5-FU to anabolites was measured under saturating substrate (5-FU) and

Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.

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Ingia / Ingia

OBJECTIVE To determine the time-dependence of fluorouracil (5FU)-induced thymidylate synthase (TS) inhibition in colon cancer patients, the effect of leucovorin (LV), and the relation to response. METHODS A 5FU injection (500 mg/m2) was given to 47 patients with advanced colorectal cancer; tumor

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Herbal & Natural Medicine

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